DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and SLC26A8

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001180405.1	Gene:	SLC26A8 / 116369	HGNCID:	14468	Length:	970	Species:	Homo sapiens

Alignment Length:	831	Identity:	190/831 - (22%)
Similarity:	350/831 - (42%)	Gaps:	187/831 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 YSIHRDVLTHEVVIKQTGYAARDKSIPSSLRN-------------CWRSWN-FFALFTGVIPILQ 85
            |.:.|:|...|.      :....|...||..|             |..||: |......:.|.|:
Human    23 YDVKREVYNEET------FQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLE 81

  Fly    86 WLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAG--VSAGNGLYMAVFPVLAYMFLGTSKHI 148
            |:..|..:..|.||::||.:|.::.:|.|:...:||.  :...|..|.|....:.|:..|:...:
Human    82 WMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQM 146

  Fly   149 SIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTIS 213
            |||:|.:.|.:...|:          ::.|.|      ||.       |:..|.:.:..|    :
Human   147 SIGSFFLVSALLINVL----------KVSPFN------NGQ-------LVMGSFVKNEFS----A 184

  Fly   214 PFQLL--NSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVV 276
            |..|:  |.:|:.       |||:..|| ||:.|:|..|.||.:::.|.|..::.:..|.|.|::
Human   185 PSYLMGYNKSLSV-------VATTTFLT-GIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIM 241

  Fly   277 TAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKC 341
            .:||..:.||.:..|.|.....|.:|:....:|:.|      ..:::.|:.:   ::..|::|..
Human   242 LSQLTFIFGIMISFHAGPISFFYDIINYCVALPKAN------STSILVFLTV---VVALRINKCI 297

  Fly   342 R-----FPL--PAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSI 399
            |     :|:  |.||.::||.|:|:...::..:.:...:..||.....||.|...|:||:.:.:.
Human   298 RISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAF 362

  Fly   400 AIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCF-SCIPMACSLSRSVIQDQTGG 463
            ::::|:..:::.:|...|..|.|.|..||:|.|:|:.|:|...| ||: ...:::|::|||::||
Human   363 SLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCV-FTGAIARTIIQDKSGG 426

  Fly   464 VSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWI 528
            ..|.||||.|.::::.::.:|.||.:||..||||:|:..:.|.......|....:|.:.:...|:
Human   427 RQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWM 491

  Fly   529 STFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRI 593
            .||...:.:.:||||:|.:..:.....::..:....|||.:|.. .||..:|.:|..:.:|.|:|
Human   492 MTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNT-NIYRSINDYREIITIPGVKI 555

  Fly   594 FRYSGSLNFATSLFFRRALYEAVGLDKIPL----------------------------------- 623
            |:...|:.|....:.:..|.:.|.:.|:||
Human   556 FQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLP 620

  Fly   624 ---------------------------------------------TKVSSSNS------------ 631
                                                         :.||..|.
Human   621 RILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWL 685

  Fly   632 -NSPSKGSKSSYSPVSQNGGKAINGKLEETS--GAFKVLVLDFSMLGHIDVAGCRTLTDLSKELK 693
             |:.|:.|......|:::.|:.......:.|  .:...::|||||:.::|..|...|..:....:
Human   686 PNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQ 750

  Fly   694 VRGARLLLASPVDRVYDTLVHSMALSEGPF--------EIFPTLHDCVEYA 736
            .....:|:|.    .:.::|.  |.....|        ::|.::||.|.:|
Human   751 NANILILIAG----CHSSIVR--AFERNDFFDAGITKTQLFLSVHDAVLFA 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	174/763 (23%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	35/250 (14%)
SLC26A8	NP_001180405.1	Sulfate_transp	92..493	CDD:279284	121/445 (27%)
		STAS	544..>584	CDD:294402	10/39 (26%)
		Interaction with RACGAP1. /evidence=ECO:0000269\|PubMed:11278976	664..970		27/138 (20%)
		STAS_SulP_like_sulfate_transporter	<719..776	CDD:132913	13/62 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	858..970
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141494
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850