Protein Alignment Prestin and SLC26A7

DIOPT Version :9

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_599028.1
• Gene: SLC26A7 / 115111
• HGNCID: 14467
• Length: 663
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 167/637 - (26%)
• Similarity: 300/637 - (47%)
• Gaps: 76/637 - (11%)

  Fly    81 IPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTS 145
            :|||.|.|.|:.:.:|..|.::|..:|:..:..|:|:.:|:.|....|||.::||.:.|...|..
Human    32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMG 96

  Fly   146 KHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSST 210
            .|::.||||:.|:::|..|:         :|:|.|...|.:..          |:|.|.
Human    97 HHVATGTFALTSLISANAVE---------RIVPQNMQNLTTQS----------NTSVLG------ 136

  Fly   211 TISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHV 275
             :|.|::          .:|.||.:::...|::.:.|..|:||:.:.:::||:::..||.||.||
Human   137 -LSDFEM----------QRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHV 190

  Fly   276 VTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKK 340
            ||:|:|.:||:.:|...|.....|....|.:.:....|......:..|..:::..| |..:..:|
Human   191 VTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKE-LNEQFKRK 254

  Fly   341 CRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVT 405
            .:..||.:|:::|..:......|:...|.:..||.||.|:|.|..|.::::..|..::..:|:|.
Human   255 IKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVG 319

  Fly   406 YSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASL 470
            |...:::....|||..|.:..|||..|.|:.|:|...|.|||.|.::.|:.....||..:|:|.|
Human   320 YVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACL 384

  Fly   471 VSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVV 535
            :|...|::.:..|||....||.||||.:|:|.||.|.:|.::|||:....|::...|:||::..:
Human   385 ISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTI 449

  Fly   536 IIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYM--------DLNQHRNAMQVPEVR 592
            ....::|||.|:..::           :.::|..|.|..:.:        .:....::..:.:|:
Human   450 CFAANVGLLFGVVCTI-----------AIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSETLQQVK 503

  Fly   593 IFRYSGSLNFATSLFFRRALYEAVGLDKI---PLTKVSSSNS----NSPSKGSKSSYSPVSQNGG 650
            |...:..|.|..:..|...|...:..:..   ||..:|....    ||.|.|:.:..:..|....
Human   504 IISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNE 568

  Fly   651 KAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLA 702
            |.             .|:||.|.....|.:|...|.::..:.|.|...:|||
Human   569 KC-------------YLILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLA 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	167/636 (26%)
		STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	27/128 (21%)
SLC26A7	NP_599028.1	sulP	33..637	CDD:273284	167/636 (26%)
		STAS_SulP_like_sulfate_transporter	495..631	CDD:132913	27/126 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810