Protein Alignment Prestin and SLC26A9

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_599152.2
• Gene: SLC26A9 / 115019
• HGNCID: 14469
• Length: 887
• Species: Homo sapiens
• Alignment Length: 779
• Identity: 211/779 - (27%)
• Similarity: 368/779 - (47%)
• Gaps: 108/779 - (13%)

  Fly    27 SKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIP--SSLRNCWR--SWNFFALFTGVIPILQWL 87
            |:|:  |:|.:.|  ..:.:.:....:..:|::.|  ..|||.:|  |....|:..|::|:|.||
Human     2 SQPR--PRYVVDR--AAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSWL 62

  Fly    88 PQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGT 152
            |:|..:..:..|::.|.:...:.:|.|||:.:||.:.|.||||.:.||:|.|.|||....:..||
Human    63 PKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGT 127

  Fly   153 FAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQL 217
            |||.|::...:.         .|:.|.:.|.:.:|.|          :.:..|:
Human   128 FAVISILVGNIC---------LQLAPESKFQVFNNAT----------NESYVDT----------- 162

  Fly   218 LNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKD 282
              :.:.|:   ::.|:.:||....|:.:.:.|::.|.::..|||..:.||.|||...::.:.||.
Human   163 --AAMEAE---RLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKY 222

  Fly   283 VLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPA 347
            :.|:::|.:.|...|::|.||:.|.:|.||:.:..|.:...||:::..| |..|...|.|||:|.
Human   223 IFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKE-LNARYMHKIRFPIPT 286

  Fly   348 ELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSM 412
            |:|:|:..|.||....:...|::..||:|..|.|.||.|.:.....:...:.::|||:|.|.::|
Human   287 EMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAM 351

  Fly   413 GLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVV 477
            |.|.|.||||:|..|||:.|:|..|..|..|....:.|:||.::..|..||.||:|||..:.:|:
Human   352 GRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVM 416

  Fly   478 VTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIG 542
            :|::.:|.:...||:.||..:|.|.||....|..:.....::.||:...|:.:||....:.:..|
Human   417 ITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYG 481

  Fly   543 LLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLF 607
            :.:|:..|:|.:..:........|..:.:. .||::...:..|..:..::|..|...|.||.|..
Human   482 VAVGVAFSVLVVVFQTQFRNGYALAQVMDT-DIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEI 545

  Fly   608 FRRALYEAVGLD--KIPLTK------------------------------------------VSS 628
            ||:.:....|:|  |:.|.|                                          ...
Human   546 FRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDP 610

  Fly   629 SNSNSPSKGSKSSY---SPVSQNGGKAINGKLEETSG-------------AFKVLVLDFSMLGHI 677
            :|:.:|:.|:..||   ||.|.:..::......|..|             .|..|:||.|.:..:
Human   611 NNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFV 675

  Fly   678 DVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLVHSMALSEGPFE---IFPTLHDCVEYANA 738
            |:.|.:.|..||......|.::.|.:...:||:.:.|.....:|..|   :||::||.|.:|.|
Human   676 DLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQA 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	192/711 (27%)
SLC26A9	NP_599152.2	PRK11660	57..561	CDD:481320	160/540 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..650		10/47 (21%)
		STAS_SulP_like_sulfate_transporter	<662..730	CDD:132913	19/67 (28%)