DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and Slc26a3

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_446207.1	Gene:	Slc26a3 / 114629	RGDID:	620623	Length:	757	Species:	Rattus norvegicus

Alignment Length:	752	Identity:	211/752 - (28%)
Similarity:	339/752 - (45%)	Gaps:	123/752 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 YSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNC--WRSWNFFALFTGVIPILQWLPQYSPRRDLP 97
            |..|:..|.|                   |:.|  ..|.....:...:.||..|||.|..:..|.
  Rat    29 YGHHKTFLDH-------------------LKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLL 74

  Fly    98 GDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAK 162
            .||::|.:..::.:..|:|:.:|..:....|||.|.|||:.|.|||||:|||:|.|.|.|||...
  Rat    75 SDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGV 139

  Fly   163 VVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNADPI 227
            ||...|:..|                   .|| .|.:|||..||:..
  Rat   140 VVTRVASGSD-------------------TSP-ALSSSSAENDSMIE------------------ 166

  Fly   228 TKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHK 292
            .|:.||.|:.:..||:.||:..|::|.:...|||.|::|||||||.||:.:|||.:|.::||.|.
  Rat   167 EKVMVAASVTVLSGIIQLLLGVLQIGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLTVPAHS 231

  Fly   293 GAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGTL 357
            ..|.|...:..|...:.:||:.:....:.::..:.:..|| ..|...|...|:|.||||.:..|.
  Rat   232 DPFSIFKVLESVFSQIQKTNIADLVTSVIILVVVFVVKEI-NQRYRSKLPVPIPIELIMTVIATG 295

  Fly   358 ISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGY 422
            ||...|....:.|..||.:..|...|:.|.:::......|...||||.:::..|:...::.|:.|
  Rat   296 ISYGCNFEQRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDCFGIAIVGFAVAFSVASVYSLKYDY 360

  Fly   423 EVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFF 487
            .:..||||.|:|:.|:..|.|.....:.:||||.:|:.|||.:|:|.|:||.:|::.::.||...
  Rat   361 PIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLL 425

  Fly   488 SSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLL 552
            ..|.:.|||.:.:..||.|.||..|:.:..|:.|.:...||.||:..:::.:.:||...:...||
  Rat   426 QPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLL 490

  Fly   553 ALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVG 617
            .:..:...|....|..:..: .||.:...:.:..:...|:|||....:.||...||::.|.:|||
  Rat   491 TIVFRTQFPKCSTLANVGRS-NIYKNKKNYADVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVG 554

  Fly   618 -------------------LDKIPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAINGKLEETSGA 663
                               |.|..|.:|:.......|.|.|.|...:..|..:.::..:..|...
  Rat   555 FNPLRILRKRNKALKKIRKLQKQGLIQVTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLP 619

  Fly   664 FKV-------------------LVLDFSMLGHIDVAGCRTL-TDLSKELKVRGARLLLASPVDRV 708
            |::                   |:||||.:..:|::..|.| |.|.:.::::         || |
  Rat   620 FEIDWNADLPLNITIPKISLHSLILDFSAVSFLDISSMRGLRTILQEFIRIK---------VD-V 674

  Fly   709 Y-----DTLVHSMALSEGPFE-------IFPTLHDCV 733
            |     |..:..:|..|. |:       .|.|:||.:
  Rat   675 YIVGTDDDFIDKLARCEF-FDDEVTDSIFFLTIHDAI 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	202/699 (29%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	43/198 (22%)
Slc26a3	NP_446207.1	Sulfate_transp	73..468	CDD:395733	143/433 (33%)
Slc26a3	NP_446207.1	STAS_SulP_like_sulfate_transporter	519..705	CDD:132913	42/196 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	279	1.000	Domainoid score	I1618
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2208
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm44790
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970