DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and SLC26A1

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_071325.2	Gene:	SLC26A1 / 10861	HGNCID:	10993	Length:	701	Species:	Homo sapiens

Alignment Length:	759	Identity:	230/759 - (30%)
Similarity:	374/759 - (49%)	Gaps:	98/759 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ESPETKPLNNNNTNGNGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLR----- 65
            ||||  ||....     |.||.:                           |.:..|..||
Human     3 ESPE--PLQQGR-----GPVPVR---------------------------RQRPAPRGLREMLKA 33

  Fly    66 NCWRSWN-----FFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSA 125
            ..|.|.:     ..||...::|..:||.||.||..|.||:::|..:.|:.:|..:||.:|||:..
Human    34 RLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQP 98

  Fly   126 GNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTA 190
            ...||.:.|..|.|..:|||:|:|:|.|::..:|..:|||         :.|.:..|....:|..
Human    99 IYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVD---------RELQLAGFDPSQDGLQ 154

  Fly   191 TASPLLLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTL 255
            ..:     |||.|..|.:        :|:...:.   ..|.|||:|.|..|:..:||..||||.:
Human   155 PGA-----NSSTLNGSAA--------MLDCGRDC---YAIRVATALTLMTGLYQVLMGVLRLGFV 203

  Fly   256 SSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTN---LVNFG 317
            |:.||:||::||...|:..::|:|||.:||:.:|||:|...::.|.:.:::|..|.|   :|...
Human   204 SAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTST 268

  Fly   318 FCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPE 382
            .|:||    ::..:.|..|...:.|.|||.||::::..||:|.:..|:..:..:..|.||:|...
Human   269 VCLAV----LLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMP 329

  Fly   383 PVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIP 447
            |.:|...|:.:||:|::|:|:|..:..:|:...||:.|||.||.||||.|:|..|::.....|..
Human   330 PQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFA 394

  Fly   448 MACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKE 512
            .:.:|::|:::..||..:|::|:|||::|::.|:.:.|.|..|.|.|||.||:|:|:....:..:
Human   395 TSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWD 459

  Fly   513 LKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYM 577
            |.:..:....:...|..|....:::..:.|||.|:.:|||:|..:..:|.:.||..:.:. ..|.
Human   460 LPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDT-AFYE 523

  Fly   578 DLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLD---KIPLTKVSSSNS----NSPS 635
            |..:....:..|.||:||:.|.|.:|...||.::||...|||   .....|...|.:    ..|:
Human   524 DATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAARRKEGGSETGVGEGGPA 588

  Fly   636 KGSKSSYSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLL 700
            :|  ....|||....      |...:..|..:|:|.:.|..:|.||..||.||.::....|..||
Human   589 QG--EDLGPVSTRAA------LVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLL 645

  Fly   701 LASPVDRVYDTLVHSMALSEGP------FEIFPTLHDCVEYANA 738
            ||.....|.|.|.....|.|||      .::|.::||.|:.|.|
Human   646 LACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARA 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	208/664 (31%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	47/160 (29%)
SLC26A1	NP_071325.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		9/50 (18%)
		sulP	55..683	CDD:273284	209/665 (31%)
		STAS_SulP_like_sulfate_transporter	528..669	CDD:132913	46/148 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141493
Domainoid	1	1.000	285	1.000	Domainoid score	I1619
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm40651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.810