Protein Alignment Prestin and slc26a3

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_031754874.1
• Gene: slc26a3 / 101732374
• XenbaseID: XB-GENE-855719
• Length: 755
• Species: Xenopus tropicalis
• Alignment Length: 761
• Identity: 208/761 - (27%)
• Similarity: 348/761 - (45%)
• Gaps: 121/761 - (15%)

  Fly    42 LTHEVVIKQTGYAA-------RDKSIPSSLRNCWRSWNFFA---LFTGVIPILQWLPQYSPRRDL 96
            |....:..:..:||       ..|:....|:.|:|.....|   ||| ..|||.|||.|:.::.|
 Frog    10 LVDRPIFSENAFAANHPKLSRNHKTFLDHLKECFRCSPQKAKQILFT-FFPILSWLPAYNFKQWL 73

  Fly    97 PGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTA 161
            .||||:|.:...:.:..|:|:.:|..:|...|||.|.||:|.|..||||:|||:|.|.|.|:|..
 Frog    74 VGDIISGISTGTVAVLQGLAFALLVNISPSYGLYSAFFPILTYFILGTSRHISVGPFPVLSLMVG 138

  Fly   162 KVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNADP 226
            ..|         .:|:|..     ||||.     |..|:..:.:.
 Frog   139 TAV---------LKIVPEG-----SNGTT-----LFANNMTIEEQ-------------------- 164

  Fly   227 ITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRH 291
              ::.||.::....||..|.:..|::|.:...||:||::||||.||..|..:|:|.:||:.:...
 Frog   165 --RVFVAGTITALAGIFQLALGLLQVGFIVIYLSDPLISGFTTGAAVLVGVSQIKFILGLKISNF 227

  Fly   292 KGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGT 356
            .|...:.||:.|:.|.:..||:.:....:.::..:.:..|: ..|...|...|:|.||||.:..|
 Frog   228 SGPLSMFYTLEDIFKKITLTNICDLVTSIIIMVVVFVVKEV-NDRFKAKIPIPIPIELIMTVIAT 291

  Fly   357 LISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHG 421
            .||...:....|.:..:|::..|...|:.|.:::..::..|..||.||.:::..|:...:|.||.
 Frog   292 GISYGCDFAGRYGIQIIGELKQGYEPPITPSVEVFQELVTDGFAIGIVAFAVGYSVAKVYALKHD 356

  Fly   422 YEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPF 486
            |.:..:|||.|.||.|:..|||....::.|||||.:|:.|||.||||.::||.:.::..:.:|..
 Frog   357 YLINGSQELVAFGISNIFCGCFRGFAVSTSLSRSAVQESTGGKSQIAGVLSALIAMIVTLAVGFL 421

  Fly   487 FSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISL 551
            ..:||:.||..::::.||.|.||..|::...::.|.:...||.||:.|||:.:|.||..|:...|
 Frog   422 LKTLPKSVLGALVLINLKGMLMQFSEIRNLWRKDKYDCSVWIVTFIAVVILGLDYGLAAGVGYEL 486

  Fly   552 LALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAV 616
            |.:..:...|...::..:..: .||.:...:....:.....||:....:.||.:.||:..:..||
 Frog   487 LTVVFRTQFPKFTVIANIGRS-DIYKNKKDYTEIYEPEGTLIFKCPSPIFFANAGFFKEKVSAAV 550

  Fly   617 GLDKI--------PLTKVS-----------------------SSNSNSPSKGSKSSYSPVSQNG- 649
            |.:.:        .|.|:|                       :|:....:...:..|:|:..|.
 Frog   551 GFNPLRILRKRNKALRKISALLKEGVLHVTPKGLVCTSYEYNASDDELDNNRVEELYNPIHPNDL 615

  Fly   650 --GKAINGKLEETSGAFKV----LVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVD-- 706
              ....|..|.......||    |:|||..:..|||:|.::|....||.......:.:|: :|
 Frog   616 PFHIDWNADLPYNIVVPKVDIHSLILDFGAVSFIDVSGMKSLKSTIKEYIRIDVDVYIAN-IDSD 679

  Fly   707 ----------------------RVYDTLVHSMALSEG---PFEIFP 727
                                  .|:|.::||:| .:|   |::|.|
 Frog   680 LLYKLENCEFFDDEIQTSIFFLTVHDAVLHSIA-KKGMKYPYDIQP 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	197/711 (28%)
slc26a3	XP_031754874.1	PRK11660	59..706	CDD:481320	189/690 (27%)