Protein Alignment Prestin and slc26a3.3

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_031754872.1
• Gene: slc26a3.3 / 101731072
• XenbaseID: XB-GENE-22062173
• Length: 775
• Species: Xenopus tropicalis
• Alignment Length: 710
• Identity: 202/710 - (28%)
• Similarity: 326/710 - (45%)
• Gaps: 101/710 - (14%)

  Fly    70 SWNFFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVF 134
            ::.||       ||..|||.|..:..:..||::|.:..::.:..|:|:.:|..|:.|.|||.|.|
 Frog    54 AYTFF-------PIASWLPMYRFKEWILSDIVSGISTGLVAVLQGLAFALLVNVTPGYGLYAAFF 111

  Fly   135 PVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLIN 199
            ||:.|.|.|||:|||:|.|.|.|:|....|...|..|
 Frog   112 PVITYFFFGTSRHISVGPFPVLSLMVGTAVLRLAPDD---------------------------- 148

  Fly   200 SSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLV 264
                 .|:|:.......:||.       .::.||.|:.:..||..|.|..|::|.:...||:.|:
 Frog   149 -----PSISANNTEALTMLNE-------KRVVVAASVTVLAGIFQLAMGLLQIGFIVIYLSDSLI 201

  Fly   265 NGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMIC 329
            :|||||||.||:.:|||.|.|:.|....|...:.||:..:...:..||:.:....:.::..:.:.
 Frog   202 SGFTTAAAIHVLVSQLKFVFGLKVEPFSGPLSLFYTLKGIFIQITDTNIADLVTSIIIMVVVFVV 266

  Fly   330 NEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKV 394
            .|| ..|...|...|:|.|:||.:..|.:|...|....|.|:.||.:..|...|:.|.|.:....
 Frog   267 KEI-NDRFKAKIPVPIPIEVIMTVIATGVSYALNFKDRYKVDIVGTLEKGFQPPIAPSLSVFQDC 330

  Fly   395 AVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQD 459
            ..|..:||||.:::..|:...::.||.|.:..||||.|.|:.|:.||||.....:.:||||.:|:
 Frog   331 VGDGFSIAIVGFAVAFSVAKVYSVKHDYVINGNQELVAFGLSNIFGGCFKGFAASTALSRSAVQE 395

  Fly   460 QTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEM 524
            .|||.:|||.::||.:|::.::.||.....|.:.||..::|:.||.|.||..||....::.|.:|
 Frog   396 STGGKTQIAGILSAIIVMIVILAIGFLIEPLQKSVLGALVIINLKGMLMQFNELPVLFRKDKYDM 460

  Fly   525 FTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVP 589
            ..||.|||..|::.:|:||..|:...||.:..:...| .|..........||.:...::|..:..
 Frog   461 LVWIVTFLGAVLLGLDLGLAAGVGFELLTVVFRAQFP-KCSQIANVGGSNIYKNRKDYKNIYEPQ 524

  Fly   590 EVRIFRYSGSLNFATSLFFRRALYEAVGLDKI-------------------------PLTKVSSS 629
            .|:|||....:.||...||:..:..|||.:.:                         |...:::|
 Frog   525 GVKIFRCPSPVFFANIEFFKDKVIAAVGFNPLRILRKRNKALRKIRKLLSKGELQWTPKGMINTS 589

  Fly   630 NSNSPS----------KGSKSSYS---PVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAG 681
            |.|..|          :..:.:|:   |::.|..:.:...:.........|:|||..:..||::|
 Frog   590 NYNIDSDEELDNNHIEELDQPTYTADLPITINWNEDLPNNISVPKIDIHSLILDFGAVSFIDMSG 654

  Fly   682 CRTLTDLSKE-LKVRGARLLLASPVDRVYDTLVHSMALSEGPFE-------IFPTLHDCV 733
            .:.|....|| ||:. ..:.:|...|.:.:.|...     |.|:       ||.::||.|
 Frog   655 MKGLKGALKEFLKIE-VDIYIAGIDDNLLEKLERC-----GFFDDEITTSIIFLSIHDAV 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	197/694 (28%)
slc26a3.3	XP_031754872.1	Sulfate_transp	73..466	CDD:459995	138/433 (32%)
		STAS_SulP_like_sulfate_transporter	517..693	CDD:132913	37/181 (20%)