Protein Alignment Prestin and slc26a4

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_017947806.2
• Gene: slc26a4 / 100498507
• XenbaseID: XB-GENE-22062177
• Length: 781
• Species: Xenopus tropicalis
• Alignment Length: 761
• Identity: 214/761 - (28%)
• Similarity: 363/761 - (47%)
• Gaps: 106/761 - (13%)

  Fly    34 KYSIHRDVLTHEVVIKQTGYAARDKS----IPSSLRNCWRSWNFFA--LFTGVIPILQWLPQYSP 92
            :|.:.|.:.|.....||....|..|:    ....||..:...:..|  :....||:|.|||:||.
 Frog    14 QYLLARPIYTQPTFEKQNMEKAPKKNTRKVFQKRLRKTFSCTSAKAVHMVKKYIPLLDWLPKYSW 78

  Fly    93 RRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVAS 157
            :.....|:::|.:..::....|:|:.:||.|..|.|:|.:.||:|.|.|||||||||:|.|.|.|
 Frog    79 KSLFVHDLVSGVSTGLVGTLQGLAFALLAEVPVGYGIYSSFFPILTYFFLGTSKHISVGPFPVIS 143

  Fly   158 MMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTL 222
            :|...||.:.|         |...|             ::.|::    :::.||    :::..|
 Frog   144 LMVGSVVLSMA---------PDKNF-------------IVYNTT----NINETT----EMIIDT- 177

  Fly   223 NADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGIS 287
            .|....::.|:.:|:..:||:.|::..|:.|.:...|:||||.||||.||.....:|:|.:|.:.
 Frog   178 EARDAARVLVSGTLSFLIGIIQLVLGALQFGFIIRYLAEPLVRGFTTGAAFQAFISQVKLILNVP 242

  Fly   288 VPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEI--LKPRLSKKCRFPLPAELI 350
            ...:.|.....||:.|:...:.:||:.:.   :|.:..:.:|..:  :..|.....|.|:|.|:|
 Frog   243 TNTYSGVLSTFYTMSDIFSNISKTNVADL---LAGLLAIFVCVAVKEINERYKHVLRIPIPIEII 304

  Fly   351 MVIGGTLISKWFNLYVD----YNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMS 411
            :    :||:.|.:...|    ||...|..||||...|:.|.:.:.|::...:|:|.||.|::.:|
 Frog   305 V----SLIAAWISYGADLENKYNAGTVKNIPSGFIPPMTPDVSMFPQIIGSAISIGIVAYAVAVS 365

  Fly   412 MGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLV 476
            :|..||.|:.|.:..|||..|.||.|:..|.|||.....:|||:.||:.|||.:|||.|:||:.|
 Frog   366 LGKVFATKYNYVIDGNQEFVAFGISNIFSGVFSCFCATTALSRTAIQESTGGKTQIAGLISAATV 430

  Fly   477 VVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDI 541
            ::|:..:|.|...|.:.|||.::|..||.||.||.::.:..||.|.:...||......:|:|:|:
 Frog   431 IITMFVLGQFLQPLQKSVLAAIVISNLKGMFWQALDIPRLWKQNKWDAAIWIFACFSTIILDLDL 495

  Fly   542 GLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSL 606
            |||.|:...|..:.::...|....||.:| ...||.||.:::|.::...::|.|:|..:.:....
 Frog   496 GLLSGLLFGLFTVILRIQFPSCHSLGNVP-GTEIYRDLKKYKNVVEQEGIKIIRFSSGIFYGNVD 559

  Fly   607 FFRRALYEAVGLDKIPL--------TKVS----------SSN---SNSPSKGSKSSYSPVSQNGG 650
            .|:..:...|..|.:.:        .|:|          :.|   :|..::..:|.:...||. .
 Frog   560 SFKNGITSIVEFDPVNVFNKRVKAQLKISELIKQGQLRVTKNGIMTNKITEDEQSEFEEDSQQ-Y 623

  Fly   651 KAINGKLEETSGAFKV-------------------LVLDFSMLGHIDVAGCRTLTDLSKELKVRG 696
            :.:..|.||..  |:|                   ::|||..:..:||....:|..:.|:.:...
 Frog   624 ENLQNKNEEME--FQVDWNSDLPVLNTVPKIFIHSIILDFGHVNFLDVVAVTSLKMILKDFRRIA 686

  Fly   697 ARLLLASPVDRVYDTLVHSMALSEGPFE-------IFPTLHDCVEY 735
            ..:..|...|.:::.|  .|.   |.||       .|.::|:.|.|
 Frog   687 VDVYFAGCDDDIFEKL--EMC---GFFEDNNKSDICFLSVHEAVIY 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	200/701 (29%)
slc26a4	XP_017947806.2	Sulfate_transp	82..482	CDD:459995	141/437 (32%)
		STAS_SulP_like_sulfate_transporter	535..719	CDD:132913	33/191 (17%)