DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and slc26a5

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_002933151.3	Gene:	slc26a5 / 100497573	XenbaseID:	XB-GENE-1000032	Length:	754	Species:	Xenopus tropicalis

Alignment Length:	756	Identity:	244/756 - (32%)
Similarity:	380/756 - (50%)	Gaps:	103/756 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 YSIHRDVLTHEVVIKQTGYAARD--KSIPSSLRNCWRSWNFFA---LFTGVIPILQWLPQYSPRR 94
            |.:.|.|.|.|.|.:|. :..:|  ||:...::...|..:..|   |:: .||||:|||:|..:.
Frog    17 YCVERPVFTQEYVEEQL-HLRKDEPKSLVHKIKQSCRCTSKKAKSQLYS-FIPILKWLPRYPVKE 79

  Fly    95 DLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMM 159
            .|.||:|:|.:..:|.:|.|:||.:||||....|||.:.:||..|.|.|:|:|||||||||.|:|
Frog    80 YLLGDVISGLSTGVMQLPQGLAYALLAGVPPVYGLYSSFYPVFLYTFFGSSRHISIGTFAVISLM 144

  Fly   160 TAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNST--- 221
            ...|....| .|:...|:|       :|||                             |||
Frog   145 IGGVAVRIA-PDEMFDIMP-------ANGT-----------------------------NSTDFD 172

  Fly   222 --LNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVL 284
              :.|....:::|..:|.|..||:.|.:..||.|.::..|:||||.|||||||.||.|:|||.:|
Frog   173 EKIEARDAMRVKVVVALTLLSGIIQLCLGILRFGFVAIYLTEPLVRGFTTAAAVHVFTSQLKYLL 237

  Fly   285 GISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAEL 349
            |:...|.:....:|::...|:..:...|:......::.|..::...|| ..|..||...|:|.|:
Frog   238 GVKTKRFREPLAVIFSFAAVLSNIMTVNVATLILGLSCILLLLGAKEI-NDRFKKKLPVPIPMEI 301

  Fly   350 IMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGL 414
            |:||..|.:|...||...:.|..|||||:|...|.||.:.|..:|.||::|||||.:|:.:||..
Frog   302 IVVIVSTGVSAGLNLEESHAVAVVGKIPTGFSPPGLPDITLFKEVFVDAVAIAIVGFSMTISMAK 366

  Fly   415 TFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVT 479
            .||.||||||..||||.|:|:.|.||..|....:.||:|||::|:.|||.:|||.|:|:.:|::.
Frog   367 IFALKHGYEVSGNQELIALGVCNSVGSFFQTFSVTCSMSRSLVQESTGGNTQIAGLLSSLMVLLV 431

  Fly   480 LMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLL 544
            ::.||..|..||:.|||.:::|.||.||.|..::....:..:||:..|:.:||..|.:.:|.|||
Frog   432 IVVIGYLFQPLPQTVLAAIVMVNLKGMFKQFADIPHLWRTSRLELSIWVVSFLASVSLGLDYGLL 496

  Fly   545 IGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFR 609
            :.:..::|.:..:...|...:||.:|.. .||.|:.|:....:..:::||:.:.||.||.|..:.
Frog   497 VAVTFAILTVIYRTQSPQYRILGQVPNT-DIYCDVEQYEEVKEFTDIKIFQANTSLYFANSELYV 560

  Fly   610 RALYEAVGLDK----IPLTKVSSSNSNSPSKGSKS------------------------SYSPVS 646
            .||.:..|:|.    |...|....::....|.:|:                        |...::
Frog   561 SALRKKTGIDPAAILIAKKKAQKRHAREMKKANKTEKKAVLKLTNDVEMAVKHELMNDDSIIDMA 625

  Fly   647 QNGGKAINGK-LEETSG-----------AFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARL 699
            .||...::.: |..|..           :...::|||:.:..:|..|.:||..:.||.|..|..:
Frog   626 ANGRNGLSERNLHNTPSDELEYFMTPIISVHWIILDFTPVNFVDSVGVKTLKSIIKEYKEIGVTV 690

  Fly   700 LLASPVDRVYDTLVHSMALSEGPFE-------IFPTLHDCV 733
            |::.....|...|.     |...|:       :|.::||.|
Frog   691 LVSGCSGLVVKDLT-----SLNFFDPSNKRDILFHSIHDAV 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	227/700 (32%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	37/194 (19%)
slc26a5	XP_002933151.3	sulP	67..725	CDD:273284	228/701 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I1472
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69472
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2181
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm47827
Panther	1	1.100	-	-	O	PTHR11814
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160