Protein Alignment Prestin and slc26a2.2

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_012815261.1
• Gene: slc26a2.2 / 100494580
• XenbaseID: XB-GENE-1214887
• Length: 737
• Species: Xenopus tropicalis
• Alignment Length: 730
• Identity: 209/730 - (28%)
• Similarity: 356/730 - (48%)
• Gaps: 88/730 - (12%)

  Fly    32 QPKYSIHRDVLTHEVVIKQT-GYAARDKSIPSSLRNCWRSWNFFALFTGVIPILQWLPQYSPRRD 95
            ||:.|      |.::::::| .|......:..|:        .|.:|    |:|||.|:|..::.
 Frog    39 QPEQS------TKDIIVEKTREYCTSGPKLLISI--------LFRIF----PVLQWFPRYKIKKY 85

  Fly    96 LPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMT 160
            |||||.:|..|.|:.||..:||.:||......|||...|..:.|.|:.||.|..:|||.|..:|.
 Frog    86 LPGDITSGLIVGIVTIPQSIAYSVLANQDPIYGLYTNFFCCIIYFFMATSHHNCVGTFGVLCLMV 150

  Fly   161 AKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNAD 225
            .:.|..           .:.|.|..::||.||             :::||.:.     |.|.:..
 Frog   151 GESVSK-----------QLQAAGYNTDGTTTA-------------AINSTLVG-----NMTCDKS 186

  Fly   226 PITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPR 290
             ...|.|||||...||:..:|:...:||.:|..|||||::||.|.::..::|:|:|.:.|:.:..
 Frog   187 -CYAITVATSLTFIVGVYQILLGVFQLGFISMYLSEPLLSGFVTGSSLTILTSQMKYLFGLKLTS 250

  Fly   291 HKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGG 355
            ..||..::.|.|||...:..||:.:....:..||.::...|| ..|...|.:.|.|.|||::|..
 Frog   251 RYGAGSLVLTWIDVFSNLKNTNICDLVTSIIAIAVIVPVKEI-NDRFKSKMKIPCPVELIVIIVA 314

  Fly   356 TLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKH 420
            ||:|.:|:.:.:|..:..|.||:|...|..|...|:|.:|.|::.|||:.:::.:|:...|||||
 Frog   315 TLVSHYFDFHNNYKASICGTIPTGFKVPRAPNWGLIPSIAADAVPIAIIGFAMTISLAEIFAKKH 379

  Fly   421 GYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGP 485
            ||.|..|||:.|:|..|.:...||......:|::|::::.||..:|...::|:|::::.|:.|.|
 Frog   380 GYTVSSNQEMIAIGTCNFITSFFSGFVSCAALTKSLLRESTGANTQFNGIISSSVLLLVLLAIAP 444

  Fly   486 FFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICIS 550
            .|.||..|||..:.|.:|:....:..:..|..:..|::...|..:.|...:|..:||||:.:|.|
 Frog   445 LFYSLQNCVLGVITITSLRGALRKFADTPKMWRISKIDTVVWWVSMLASSLITTEIGLLVAVCFS 509

  Fly   551 LLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEA 615
            :|.:..:..:|.:.||..: ....||.|...::....:|.|:|:|:..||.:|...:|:..||..
 Frog   510 ILCVIFRTQRPRATLLAKV-TGTEIYEDQFTYKELSNIPNVKIYRFDASLYYANKDYFKTTLYSK 573

  Fly   616 VGLDKIPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAI--------NGKLEETSGA----FKV-- 666
            ..::       .|..|....|..|...:...:...:.|        :||:.:::..    |.:
 Frog   574 TDIN-------PSLVSALQKKAKKEEEAAAIETKNRFIARFNIIKTSGKIRQSASVSVPQFDIHS 631

  Fly   667 LVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLLLASPVDRVYDTLVHSMALSEGPF-------- 723
            |::|...:..||..|...|.::..:.:..|.|:.||:     .:..|.|| ||.|.:
 Frog   632 LIIDCGAMQFIDTVGLGVLKEVKNDYEEIGIRVFLAN-----CNPSVRSM-LSNGGYMNNASSGI 690

  Fly   724 --EIFPTLHDCVEYA 736
              .||.::||.|.:|
 Frog   691 DLHIFHSVHDAVNFA 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	196/672 (29%)
slc26a2.2	XP_012815261.1	sulP	72..701	CDD:273284	197/673 (29%)