Protein Alignment Prestin and slc26a11

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: XP_002937354.2
• Gene: slc26a11 / 100486579
• XenbaseID: XB-GENE-955145
• Length: 594
• Species: Xenopus tropicalis
• Alignment Length: 699
• Identity: 166/699 - (23%)
• Similarity: 270/699 - (38%)
• Gaps: 206/699 - (29%)

  Fly    81 IPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTS 145
            :|.|||||:|| .:.|..|||||.||.:..:|..:||..:||:....|||.:......|.|||||
 Frog    30 LPFLQWLPRYS-LQWLQLDIIAGITVGLTVVPQALAYAEVAGLPVQFGLYSSFVGCFIYCFLGTS 93

  Fly   146 KHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSST 210
            |.:::|..|:.|                                      ||:....|.|
 Frog    94 KDVTLGPTAIMS--------------------------------------LLVFVYTLGD----- 115

  Fly   211 TISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHV 275
                               :.:|..|....|.:.|.|..|..|.|...:|.|::..||:|||..:
 Frog   116 -------------------LSLAILLTFISGCIQLAMGLLNFGFLLDFISYPVIKAFTSAAAITI 161

  Fly   276 VTAQLKDVLGI-SVPRHKGAFKIIYTVIDVIKGVPQT---NLVNFGFCMAVIAF----------- 325
            ..:|:|::||: .:||     :.|..|....:.:|.|   :.:....|:|::..
 Frog   162 AFSQVKNLLGLQDIPR-----QFILQVYQTFRKLPSTRPGDAILGILCIAILLALKWMKDHTSRP 221

  Fly   326 ---MMICNEILKPRLSKKCR-----FPLPAELIMVIGGTLISKWFNLYVDYNVNP---VGKIPSG 379
               |.||:.|        |.     .......::|:|..|::..|::   ..::|   .||...|
 Frog   222 YQGMSICHRI--------CYLIVWIMTTARNALIVVGAGLVAYSFHV---MGLHPFILTGKTAKG 275

  Fly   380 LPEPVLPRL-DLVP---KVAVDSIAIAIVTYSIIMSMGL--------TFAKKHGYEVRPNQELFA 432
            ||:..||.. ::.|   |...:.:.:......||..|||        .||.::.|.::.||||.|
 Frog   276 LPQFQLPPFSEITPNGTKTFSEMVQVIGSGILIIPLMGLLESVAIARAFASQNNYRIKTNQELLA 340

  Fly   433 MGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAG 497
            :|:.|::|...|..|:..|..|:.:..|||..:....:::..||:::|.::.|.|..:|:..||.
 Frog   341 IGLTNILGSFLSSYPVTGSFGRTALNSQTGVCTPAGGIITGLLVLLSLGYLTPAFYFIPKAALAA 405

  Fly   498 VIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPY 562
            |||.|:.||| ..:..|...|..:|::..:..||| :...:|..|:|.|..:|::.|
 Frog   406 VIICAVAPMF-DLRICKSMWKVKRLDLIPFFVTFL-LSFWEIQYGILAGTFVSIIFL-------- 460

  Fly   563 SCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSG-------SLNFATSLFFRRALYEAVGLDK 620
             |    .|.|.               ||:::....|       .|:|....:.:..:||..
 Frog   461 -C----YPIAR---------------PEIKVSDMDGLILTPMSGLSFPAMEYLKDKIYEKT---- 501

  Fly   621 IPLTKVSSSNSNSPSKGSKSSYSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRTL 685
               ..|||..|                                   :.|||:.:..||......|
 Frog   502 ---FTVSSPQS-----------------------------------VTLDFTHVTAIDYTVVVGL 528

  Fly   686 TDLSKELKVRGARLL---LASPVDRVYDTL-------VHSMALSEGPFE 724
            .:|..|.|.:|..|.   |..|:..::.:.       .||:..|.|.|:
 Frog   529 AELLSEFKAQGVCLTFSGLQPPLLHMFSSSGLTELHHFHSIETSGGSFQ 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	166/698 (24%)
slc26a11	XP_002937354.2	SUL1	38..563	CDD:440424	155/675 (23%)