DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and slc26a4l

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001120492.2	Gene:	slc26a4l / 100145611	XenbaseID:	XB-GENE-22062185	Length:	768	Species:	Xenopus tropicalis

Alignment Length:	758	Identity:	216/758 - (28%)
Similarity:	356/758 - (46%)	Gaps:	101/758 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSW--NFFALFTGVIPILQW 86
            ||.|:|..|.::. .|:::              .|.....|:|.:...  ..|.:...:||:|.|
Frog    14 SVYSEPAFQEQHE-KREII--------------HKPFKQKLKNTFSCTPKKAFGIAKTLIPVLDW 63

  Fly    87 LPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIG 151
            ||:|..:..:..|||||.:|.:::...|:|:|::|||....|||.:.||||.|.|.|||:|||:|
Frog    64 LPKYRWKEWILQDIIAGVSVGLISALQGLAFGLMAGVPIQFGLYSSFFPVLMYCFFGTSRHISVG 128

  Fly   152 TFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQ 216
            .|.|..:|...|..:.|         |...|.:..|||.||.      .:|..|:
Frog   129 PFPVVCLMVGIVTISMA---------PDEQFAITINGTETAI------DTAARDA---------- 168

  Fly   217 LLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLK 281
                       .:|.:..:|...:||:.|.:...::|.:...|::||:.|||||||..|...|:|
Frog   169 -----------ARISICGTLTFLIGILQLSLGVFQIGFIVRYLADPLIGGFTTAAAFQVTVTQIK 222

  Fly   282 DVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLP 346
            .:|.:....:.|...||||:||:...:.|||..:....:..:..:::..|| ..|..:|.|.|:|
Frog   223 TILNVPAKNYNGVLSIIYTIIDIFSNIAQTNFADLIAGLLTLVIVLVVKEI-NERYKEKIRIPIP 286

  Fly   347 AELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMS 411
            .|:|:.|..|.||...||...||...:..||||...|..|.:.|..::...:.:|.||.|:|.:|
Frog   287 IEIIVTIVATGISYGANLAGKYNAGIIKTIPSGFIPPASPDVSLFSQLISSAFSIGIVAYAIAIS 351

  Fly   412 MGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLV 476
            :|..:..|:.|:|..|||..|.||.||..|.|||...:.:|||:.||:.|||.:|||.::||.:|
Frog   352 VGKVYGTKNNYKVNGNQEFIAFGISNMFAGVFSCFCASTALSRTAIQEGTGGKTQIAGMISALMV 416

  Fly   477 VVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDI 541
            ::.::.||.....|.:.|||.:::..||.|:||.:::....:|.:.:...|:.|.:..:|:.:|:
Frog   417 LIAIVAIGRLLEPLQKSVLAAIVVANLKGMYMQVRDIPVLWRQNRWDAVIWVFTCISAIILGLDL 481

  Fly   542 GLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSL 606
            |||.|:...||.:.::...|....|..:|.. .:|.|:..::..::...|||.|:|..:.:....
Frog   482 GLLAGLVFGLLTVVLRVQFPSCTSLANIPHT-DLYKDVKIYKELIEPGGVRIIRFSSGIFYGNIE 545

  Fly   607 FFRRALYEAVGLDKI--------PLTKVSS---------------SNSNSPSKGSKSSYSP---- 644
            ..:..:.:.||.|..        .|.::..               |.|...::|.:....|
Frog   546 GLKSGIKKIVGFDAARVFNKRTKALRRIEKLIKKGQLGATWNGIVSGSGMDNEGFEPDDEPDDQE 610

  Fly   645 VSQNGGKAI-----------NGKLEETSGAFKV----LVLDFSMLGHIDVAGCRTLTDLSKELKV 694
            |.||  :.|           |..|..|....||    ::.||:.:..:||...::|..:.||.|.
Frog   611 VEQN--QEIHTNEVEIQVDWNSDLPLTVSVPKVTVHTIIFDFAQVAFLDVVAVKSLKLIYKEFKR 673

  Fly   695 RGARLLLASPVDRVYDTLVHSMALSEG--PFEIFPTLHDCVEY 735
            ....:.:|:..|:||:.:.......:.  |...|.|:||.:.|
Frog   674 IDVDIYIAACDDKVYNKMEICGFFDDAIKPDIFFLTVHDAMLY 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	202/692 (29%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	37/191 (19%)
slc26a4l	NP_001120492.2	sulP	59..713	CDD:273284	203/693 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2181
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm47827
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060