Protein Alignment Prestin and slc26a4l

DIOPT Version :10

• Sequence 1: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Sequence 2: NP_001120492.2
• Gene: slc26a4l / 100145611
• XenbaseID: XB-GENE-22062185
• Length: 768
• Species: Xenopus tropicalis
• Alignment Length: 758
• Identity: 216/758 - (28%)
• Similarity: 356/758 - (46%)
• Gaps: 101/758 - (13%)

  Fly    24 SVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSW--NFFALFTGVIPILQW 86
            ||.|:|..|.::. .|:::              .|.....|:|.:...  ..|.:...:||:|.|
 Frog    14 SVYSEPAFQEQHE-KREII--------------HKPFKQKLKNTFSCTPKKAFGIAKTLIPVLDW 63

  Fly    87 LPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIG 151
            ||:|..:..:..|||||.:|.:::...|:|:|::|||....|||.:.||||.|.|.|||:|||:|
 Frog    64 LPKYRWKEWILQDIIAGVSVGLISALQGLAFGLMAGVPIQFGLYSSFFPVLMYCFFGTSRHISVG 128

  Fly   152 TFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQ 216
            .|.|..:|...|..:.|         |...|.:..|||.||.      .:|..|:
 Frog   129 PFPVVCLMVGIVTISMA---------PDEQFAITINGTETAI------DTAARDA---------- 168

  Fly   217 LLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLK 281
                       .:|.:..:|...:||:.|.:...::|.:...|::||:.|||||||..|...|:|
 Frog   169 -----------ARISICGTLTFLIGILQLSLGVFQIGFIVRYLADPLIGGFTTAAAFQVTVTQIK 222

  Fly   282 DVLGISVPRHKGAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLP 346
            .:|.:....:.|...||||:||:...:.|||..:....:..:..:::..|| ..|..:|.|.|:|
 Frog   223 TILNVPAKNYNGVLSIIYTIIDIFSNIAQTNFADLIAGLLTLVIVLVVKEI-NERYKEKIRIPIP 286

  Fly   347 AELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMS 411
            .|:|:.|..|.||...||...||...:..||||...|..|.:.|..::...:.:|.||.|:|.:|
 Frog   287 IEIIVTIVATGISYGANLAGKYNAGIIKTIPSGFIPPASPDVSLFSQLISSAFSIGIVAYAIAIS 351

  Fly   412 MGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLV 476
            :|..:..|:.|:|..|||..|.||.||..|.|||...:.:|||:.||:.|||.:|||.::||.:|
 Frog   352 VGKVYGTKNNYKVNGNQEFIAFGISNMFAGVFSCFCASTALSRTAIQEGTGGKTQIAGMISALMV 416

  Fly   477 VVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDI 541
            ::.::.||.....|.:.|||.:::..||.|:||.:::....:|.:.:...|:.|.:..:|:.:|:
 Frog   417 LIAIVAIGRLLEPLQKSVLAAIVVANLKGMYMQVRDIPVLWRQNRWDAVIWVFTCISAIILGLDL 481

  Fly   542 GLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSL 606
            |||.|:...||.:.::...|....|..:|.. .:|.|:..::..::...|||.|:|..:.:....
 Frog   482 GLLAGLVFGLLTVVLRVQFPSCTSLANIPHT-DLYKDVKIYKELIEPGGVRIIRFSSGIFYGNIE 545

  Fly   607 FFRRALYEAVGLDKI--------PLTKVSS---------------SNSNSPSKGSKSSYSP---- 644
            ..:..:.:.||.|..        .|.::..               |.|...::|.:....|
 Frog   546 GLKSGIKKIVGFDAARVFNKRTKALRRIEKLIKKGQLGATWNGIVSGSGMDNEGFEPDDEPDDQE 610

  Fly   645 VSQNGGKAI-----------NGKLEETSGAFKV----LVLDFSMLGHIDVAGCRTLTDLSKELKV 694
            |.||  :.|           |..|..|....||    ::.||:.:..:||...::|..:.||.|.
 Frog   611 VEQN--QEIHTNEVEIQVDWNSDLPLTVSVPKVTVHTIIFDFAQVAFLDVVAVKSLKLIYKEFKR 673

  Fly   695 RGARLLLASPVDRVYDTLVHSMALSEG--PFEIFPTLHDCVEY 735
            ....:.:|:..|:||:.:.......:.  |...|.|:||.:.|
 Frog   674 IDVDIYIAACDDKVYNKMEICGFFDDAIKPDIFFLTVHDAMLY 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	202/692 (29%)
slc26a4l	NP_001120492.2	PRK11660	59..713	CDD:481320	203/693 (29%)