DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prestin and slc26a6

DIOPT Version :9

Sequence 1:	NP_649024.1	Gene:	Prestin / 39996	FlyBaseID:	FBgn0036770	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_001344243.4	Gene:	slc26a6 / 100005108	ZFINID:	ZDB-GENE-081105-83	Length:	747	Species:	Danio rerio

Alignment Length:	762	Identity:	237/762 - (31%)
Similarity:	377/762 - (49%)	Gaps:	104/762 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 YSIHRDVLTHEVVIKQTGYAARDKSIPSSLRNCWRSWNFFA--LFTGVIPILQWLPQYSPRRDLP 97
            |.|.|:||....|.:....:..:.|:...|::..|.....|  .|...||:|.|||:|..|.:..
Zfish    14 YHIQREVLDELSVDQVAEKSDFNISVKEKLKDAVRCTGPKAKSCFLSFIPLLAWLPKYPFRENAI 78

  Fly    98 GDIIAGFTVAIMNIPHGMAYGILAGVSAGNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAK 162
            ||:|:|.:|.||::|.||||.:||.|....|||.:.:|:|.|...|||||||:||:||.|:|...
Zfish    79 GDLISGISVGIMHLPQGMAYALLAAVPPVFGLYSSFYPILIYFIFGTSKHISVGTYAVMSVMIGS 143

  Fly   163 VVDTYANVDDHHQILPINAFGLQSNGTATASPLLLINSSALADSVSSTTISPFQLLNSTLNADPI 227
            |.:         ::.|.:.|....|.|                  :||.|.     .|:.:|:
Zfish   144 VTE---------RLAPDSDFTFPGNET------------------NSTYID-----FSSRDAE-- 174

  Fly   228 TKIEVATSLALTVGIVNLLMAFLRLGTLSSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHK 292
             ::::|.::....||..||:..:|.|.:.:.||||||..:|||||.||:.:|||...||:..|:.
Zfish   175 -RVKIAATVTFLSGIFQLLLGVVRFGFVVTYLSEPLVRSYTTAAAIHVIVSQLKYSFGINPHRYS 238

  Fly   293 GAFKIIYTVIDVIKGVPQTNLVNFGFCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGTL 357
            |...:|||||::...:.:||:......:..|..::|..| |....:||...|:|.|||.:|..|:
Zfish   239 GPLSLIYTVIEICALLGKTNIGTLVVSIVTIVGLIIAKE-LSALAAKKIPIPIPVELITIIIATV 302

  Fly   358 ISKWFNLYVDYNVNPVGKIPSGLPEPVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGY 422
            :|.:.:|...|.|..||:|||||..||.|::..:..:..|:.|:|:|.|.|.:|:|..||.|:.|
Zfish   303 VSWYMDLKTIYKVEVVGEIPSGLQAPVAPKVSQLGSMVGDAFALAVVGYGIAISLGRIFALKYAY 367

  Fly   423 EVRPNQELFAMGIGNMVGGCFSCIPMACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFF 487
            :|..||||.|:|:.|.:||.|||..::||:|||::|..|||.||:|..:||.:::|.|:.||..|
Zfish   368 KVDSNQELIALGLSNSIGGLFSCFAISCSMSRSMVQVSTGGKSQVAGAISALVILVILLKIGELF 432

  Fly   488 SSLPRCVLAGVIIVALKPMFMQAKELKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLL 552
            ..||:.|||.:|.|.|:.|..|..::....:..|::|..|:.|.:..::.:.|:||...|..|:|
Zfish   433 EELPKAVLAAIIYVNLQGMMKQFGDICSLWRTNKVDMVVWVMTMILTILFNPDMGLAASIAFSIL 497

  Fly   553 ALYIKGLKPYSCLLGYMPEAPGIYMDLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVG 617
            .:..:...|...:||.:| ...||..:..:....::|.:.|||.|.:|.||.:..:..||||..|
Zfish   498 TVVFRTQLPKYSILGQIP-GTDIYKPVEDYNQVKEIPGITIFRSSATLYFANAEMYIDALYEKTG 561

  Fly   618 LDKIPL----TKVSSSNSNSPSKGSKSSYSPVSQNGGKA-------------------------- 652
            :|...|    .|:.:.......|.:|.:.....:...:|
Zfish   562 VDVAKLLSHKKKLQAKRLRKEKKAAKKAKKEAKKRAKEAARQAKEEPVFSDTEESEEEPELVSHS 626

  Fly   653 -INGKLEETS------------GAF--------KVLVLDFSMLGHIDVAGCRTLTDLSKELKVRG 696
             .||.:.|.|            |.:        |.::||.:.:..:|..|.:||.::.|:....|
Zfish   627 QTNGNVHELSVKEPKDMVVVEAGPYTDPDTPLPKAIILDLNPVNFLDTVGVKTLRNIYKDYGEAG 691

  Fly   697 ARLLLASPVDRVYDTLVHSMALSEGPF--------EIFPTLHDCVEY 735
            .::.|......|.:      ::.:|.|        .:|.|:||.|.|
Zfish   692 VQIYLCGCQRGVVE------SMEKGDFFNEKVTKSILFSTVHDAVLY 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prestin	NP_649024.1	sulP	82..731	CDD:273284	221/707 (31%)
Prestin	NP_649024.1	STAS_SulP_like_sulfate_transporter	582..730	CDD:132913	39/206 (19%)
slc26a6	XP_001344243.4	sulP	63..729	CDD:273284	222/708 (31%)
slc26a6	XP_001344243.4	STAS_SulP_like_sulfate_transporter	<655..725	CDD:132913	14/75 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1407
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1977
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm25589
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	O	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900