Protein Alignment Tsp74F and TSPAN14

DIOPT Version :10

• Sequence 1: NP_524132.1
• Gene: Tsp74F / 39995
• FlyBaseID: FBgn0036769
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_112189.2
• Gene: TSPAN14 / 81619
• HGNCID: 23303
• Length: 270
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 63/262 - (24%)
• Similarity: 120/262 - (45%)
• Gaps: 36/262 - (13%)

  Fly     4 SSRMDCCGQFVKYSLFIANFVIFVGGAIVFCLTLWTLVDRSFVNELLGTNLFSG--AVYVLLVTS 66
            ::::.|   :.||.||..|.:.::.|.:...:.||...::..:::|.......|  .|.::|:..
Human     8 NAKVSC---WYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVG 69

  Fly    67 IIICLVSFLGCVGAGKEVKCLLLTYFIIVALVFVTMLIGGVLGYVFRERVQQTMRQEMRSTMALY 131
            :::..:.|.|||||.:|..|||..:...:.|:|...|...||.::|::.|:...|:...|.:..|
Human    70 VVMFTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSY 134

  Fly   132 GSRREITQAWDLTQERLQCCGVDTWHDWN---------------RYGPVPESCC-----QELFGG 176
            ....::....|..|:..||||.....||:               :.| ||.|||     |::...
Human   135 RDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCG-VPFSCCVPDPAQKVVNT 198

  Fly   177 QRKECTIFPTI-------TNLYNQGCLYVTTNFIRDHAAVIGGTSIAVAILMIFGMIFSCLLFNM 234
            |   |.....|       .:::.:||:....:::..:..::.|..||:::|.|||:..:..|.:.
Human   199 Q---CGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISD 260

  Fly   235 IE 236
            ||
Human   261 IE 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp74F	NP_524132.1	Tetraspanin	14..233	CDD:459767	60/247 (24%)
		NET-5_like_LEL	110..207	CDD:239418	25/123 (20%)
TSPAN14	NP_112189.2	Tetraspanin	16..258	CDD:459767	59/245 (24%)
		TM4SF9_like_LEL	113..233	CDD:239412	25/123 (20%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000269|PubMed:26668317	114..232		25/121 (21%)