Protein Alignment Tsp74F and PRPH2

DIOPT Version :10

• Sequence 1: NP_524132.1
• Gene: Tsp74F / 39995
• FlyBaseID: FBgn0036769
• Length: 236
• Species: Drosophila melanogaster
• Sequence 2: NP_000313.2
• Gene: PRPH2 / 5961
• HGNCID: 9942
• Length: 346
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 53/280 - (18%)
• Similarity: 98/280 - (35%)
• Gaps: 98/280 - (35%)

  Fly    18 LFIANFVIFVGGAIVFCLTLWTLVD---RSFV----------NELLGTNLFSGAVYVLLVTSIII 69
            |::.|:...:.|.|:|.|.|:..::   ||.|          |.|:|..:.|
Human    20 LWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSESHFVPNSLIGMGVLS------------- 71

  Fly    70 CLVSFLGCVGAGK------------EVKCLLLTYFIIVALVFVTMLIGGVLGYVFRERVQQTMRQ 122
            |:.:.|    |||            ..|..|..|..|..|..:.:.:..:..::.|..::.|:.|
Human    72 CVFNSL----AGKICYDALDPAKYARWKPWLKPYLAICVLFNIILFLVALCCFLLRGSLENTLGQ 132

  Fly   123 EMRSTMALY-----GSRREITQAWDLTQERLQCCGVDTWHDW-------NRY------------- 162
            .:::.|..|     ..|..:.:..|:.|...:|||.:.:.||       |||
Human   133 GLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIK 197

  Fly   163 ---------GPVPESCCQELFGGQRKECTIFPTIT---------------NLYNQGCLYVTTNFI 203
                     ..||.|||..   ...:.|..: .||               ||:.:||.....::
Human   198 SNVDGRYLVDGVPFSCCNP---SSPRPCIQY-QITNNSAHYSYDHQTEELNLWVRGCRAALLSY- 257

  Fly   204 RDHAAVIGGTSIAVAILMIF 223
              :::::....:...::.:|
Human   258 --YSSLMNSMGVVTLLIWLF 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp74F	NP_524132.1	Tetraspanin	14..233	CDD:459767	53/280 (19%)
		NET-5_like_LEL	110..207	CDD:239418	28/145 (19%)
PRPH2	NP_000313.2	Tetraspanin	16..181	CDD:459767	37/177 (21%)
		peripherin_like_LEL	120..262	CDD:239415	28/148 (19%)
		Interaction with MREG. /evidence=ECO:0000250	341..346