DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp74F and Tspan8

DIOPT Version :9

Sequence 1:	NP_524132.1	Gene:	Tsp74F / 39995	FlyBaseID:	FBgn0036769	Length:	236	Species:	Drosophila melanogaster
Sequence 2:	NP_598210.1	Gene:	Tspan8 / 171048	RGDID:	621783	Length:	235	Species:	Rattus norvegicus

Alignment Length:	238	Identity:	65/238 - (27%)
Similarity:	116/238 - (48%)	Gaps:	29/238 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VKYSLFIANFVIFVGGAIVFCLTLWTLVDRSFVNELL-----GTNLFSGAVYVLLVTSIIICLVS 73
            :|||:|..||:.:|.|.::..|.:|..|.:. ..|::     |||.|. ||.:|:....||.::.
  Rat     8 LKYSMFFFNFLFWVCGTLILGLAIWLRVSKD-GKEIITSGDNGTNPFI-AVNILIAVGSIIMVLG 70

  Fly    74 FLGCVGAGKEVKCLLLTYFIIVALVFVTMLIGGVLGYVFRER----VQQTMRQEMRSTMALYGSR 134
            ||||.||.||.:|:||.:||.:.|:.:..:..|:||..|:..    :.:|:.:..:.........
  Rat    71 FLGCCGAVKESRCMLLLFFIGLLLILLLQVAAGILGATFKSESSRILNETLYENAKLLSETSNEA 135

  Fly   135 REITQAWDLTQERLQCCGVDTW-HDWNRYGPVPESCCQ------ELFGGQRKECTIFPTITNLYN 192
            :|:.:|....|...:|||:... .||.:..|..:..||      |.:.|:           |:|.
  Rat   136 KEVQKAMIAFQSEFKCCGLRFGAADWGKNFPDAKESCQCTGSDCESYNGE-----------NVYR 189

  Fly   193 QGCLYVTTNFIRDHAAVIGGTSIAVAILMIFGMIFSCLLFNMI 235
            ..||.:....:..:..::.|.:..:|::.|.|::||.:|:..|
  Rat   190 TTCLSLIKELVEKNIIIVIGIAFGLAVIEILGLVFSMVLYCQI 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp74F	NP_524132.1	Tetraspannin	14..231	CDD:395265	63/232 (27%)
Tspan8	NP_598210.1	Tetraspannin	8..228	CDD:395265	63/232 (27%)
Tspan8	NP_598210.1	TM4SF3_like_LEL	106..204	CDD:239407	20/108 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19282
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X124
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910