DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7402 and arsj

DIOPT Version :9

Sequence 1:	NP_649023.1	Gene:	CG7402 / 39994	FlyBaseID:	FBgn0036768	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_688265.3	Gene:	arsj / 559800	ZFINID:	ZDB-GENE-111215-1	Length:	568	Species:	Danio rerio

Alignment Length:	585	Identity:	197/585 - (33%)
Similarity:	293/585 - (50%)	Gaps:	79/585 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILVLLVVSSILSLAYG---SGY-----------STKPNIVIILIDDMGMNDVSFHGSNQILTPNI 56
            :.:|...|.|:|..||   ||:           :::|:|:.|::||.|..||.:||| :|.||.:
Zfish    17 LTLLTTFSCIVSSTYGTWKSGFQSNLVNNMDKPNSQPHIIFIMVDDQGFRDVGYHGS-EIKTPTL 80

  Fly    57 DALAYNGILLNKHYVPNLCTPSRATLLTGKYPIHTGMQHFVIITDEPWGLPQRERLMPEIFRDAG 121
            |.||..|:.|..:||..||:|||:.|:||:|.||||:||.:|...:|..||.....:|:..::||
Zfish    81 DRLAAAGVKLENYYVQPLCSPSRSQLMTGRYQIHTGLQHSIIRPTQPNCLPLENITLPQKLKNAG 145

  Fly   122 YSTHLVGKWHLGFWRKDLTPTMRGFDHHFGYYNGYIDYYDHQVRMLDRNYSAGLDFRRDLEPCPE 186
            ||||:||||||||:::...||.||||..||...|..|||.|.  ..|.....|.|.....|...|
Zfish   146 YSTHMVGKWHLGFYKRACMPTQRGFDTFFGSLLGSGDYYSHY--KCDSPGLCGYDLHEGEEAAWE 208

  Fly   187 AN-GTYATEAFTSEAKRIIEQHDKSKPLFMVLSHLAVHTGNEDSPMQAPEEEVAKFPHIRDPKRR 250
            .: |.|:|..:|.:|..|:..|:..:|:|:.|:..|||     ||:|.|...:.::..|.:..||
Zfish   209 QDRGVYSTIMYTQKAVNILASHNPKRPIFLYLAFQAVH-----SPLQVPARYLERYKSIPNLHRR 268

  Fly   251 TYAGMISSLDKSVAQTIGALKDNGMLNNSIILLYSDNGA-PTIGIHSNAGSNYPYRGQKESPWEG 314
            .||.|:|.||::|.....|||..|..:|.:::..||||. |..|     |||:|.||.|.|.|||
Zfish   269 KYAAMVSCLDEAVRNLTLALKQYGYYDNMVMVYSSDNGGQPMAG-----GSNWPLRGSKGSYWEG 328

  Fly   315 GIRSAGALWSPLLKERGYVSNQAIHAVDWLPTLAGAAGVSLPQDLPLDGINLWPMLSGNEEPKPR 379
            |||:.|.:.||||.::|..|...||..||.|||......:|.::..|||.::|..:| ...|.||
Zfish   329 GIRAVGFVHSPLLVKKGTKSKALIHITDWYPTLVMLGEGTLDENQNLDGYDVWEAIS-EGRPSPR 392

  Fly   380 -TMIHVLDEVFGYSSYMRDTLKYVNGSSFKGRYDQW---------LGELETNEDDPLGESYEQHV 434
             .::|.:|.::         .|..|| |:|..|..|         :|:.:.....|   .|...:
Zfish   393 LDILHNIDPIY---------TKAKNG-SWKAGYGIWNTAVQAALRVGDWKLLTGVP---GYSDWI 444

  Fly   435 LASDVQSLLGNRGLTKDRIRQMRSEATETCPPIEGQNPLESHFKCEPLKAPCFFDLAKDPCERYN 499
            ......:||.......:|:...|.                        |:...|::..||.||.:
Zfish   445 PPQTFSTLLLANRWHNERVSWDRG------------------------KSVWLFNITADPYERVD 485

  Fly   500 LAQMYPLQLQQLADELEQIRKTAIPSARVPHSDSRANPTFHNGNW-EWWNNTDTQSGSGTFSINL 563
            |::.||..::::..:|.:..|.|:| .|.|..|.|:||.::.|.| .|:.:.|........|.:|
Zfish   486 LSRQYPHVVKKMLFKLLRYSKNAVP-CRYPPKDYRSNPQYNGGVWGPWYTDDDQDEDDNLLSYDL 549

Fly 564 563
Zfish 550 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7402	NP_649023.1	PRK13759	25..459	CDD:237491	164/445 (37%)
CG7402	NP_649023.1	4-S	28..436	CDD:293753	160/419 (38%)
arsj	XP_688265.3	AslA	47..501	CDD:225661	173/504 (34%)
arsj	XP_688265.3	4-S	53..487	CDD:293753	170/484 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592903
Domainoid	1	1.000	294	0.414	Domainoid score	I1467
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2236
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm6503
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.660