DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7402 and SULF2

DIOPT Version :9

Sequence 1:	NP_649023.1	Gene:	CG7402 / 39994	FlyBaseID:	FBgn0036768	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001373981.1	Gene:	SULF2 / 55959	HGNCID:	20392	Length:	871	Species:	Homo sapiens

Alignment Length:	672	Identity:	131/672 - (19%)
Similarity:	227/672 - (33%)	Gaps:	211/672 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ILVLLVVSSILSLAYGSG----------------YSTKPNIVIILIDDMGMNDVSFHGSNQILTP 54
            :::.|:.:::.||..||.                .:.:|||:::|.||   .||.. ||.|::..
Human     6 LVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDD---QDVEL-GSMQVMNK 66

  Fly    55 NIDALAYNGI-LLNKHYVPNLCTPSRATLLTGKYPIHTGMQHFVIITDE-----PWGLPQRERLM 113
            ....:...|. .:|......:|.|||:::||||| :|   .|.....:|     .|......|..
Human    67 TRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKY-VH---NHNTYTNNENCSSPSWQAQHESRTF 127

  Fly   114 PEIFRDAGYSTHLVGKWHLGFWRKDLTPTMRGFDHHFGYYNG-YID--------------YYDHQ 163
            .......||.|...||                   :...||| |:.              :|::.
Human   128 AVYLNSTGYRTAFFGK-------------------YLNEYNGSYVPPGWKEWVGLLKNSRFYNYT 173

  Fly   164 VRMLDRNYSAGLDFRRDLEPCPEANGTYATEAFTSEAKRIIEQHDK---SKPLFMVLSHLAVHTG 225
            :.........|.|:.:|          |.|:..|:::........|   .:|:.||:||.|.| |
Human   174 LCRNGVKEKHGSDYSKD----------YLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPH-G 227

  Fly   226 NEDSPMQ------------------APEEE---VAKFPHIRDPKRRTYAGMIS--------SLDK 261
            .|||..|                  ||..:   :.::.....|....:..|:.        |:|.
Human   228 PEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMSVDD 292

  Fly   262 SVAQTIGALKDNGMLNNSIILLYSDNGAPTIGIHSNAGSNYPYRGQ------KESPWEGGIRSAG 320
            |:......|.:.|.|:|:.|:..:|:|.              :.||      |..|:|..||...
Human   293 SMETIYNMLVETGELDNTYIVYTADHGY--------------HIGQFGLVKGKSMPYEFDIRVPF 343

  Fly   321 ALWSPLLKERGYVSNQAIHAVDWLPTLAGAAGVSLPQDLPLDGINLWPMLSGNEEPKPRTMIHVL 385
            .:..|.: |.|.::...:..:|..||:...||:.:|.|  :||.::..:|
Human   344 YVRGPNV-EAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL--------------- 390

  Fly   386 DEVFGYSSYMRDTLKYVNGSSFKGRYDQW-------LGELETNEDDPLGESYEQHVLASDVQSLL 443
                       ||.:.||....|.:...|       .|:|....|:...::.|::.|..
Human   391 -----------DTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPK------ 438

  Fly   444 GNRGLTKDRIRQM--RSEATETCPPI--------EGQNPLESHFKCE-PLK----------APCF 487
                  ..|::.:  |:|....|..:        :....|:.| ||: |::          .|.:
Human   439 ------YQRVKDLCQRAEYQTACEQLGQKWQCVEDATGKLKLH-KCKGPMRLGGSRALSNLVPKY 496

  Fly   488 FDLAKDPCE------RYNLA----QMYPLQLQQLADELEQIRKTAIP-SARVPH---SDSRANPT 538
            :....:.|.      :.:||    :::..:.:........||..||. ..||.|   .|:.....
Human   497 YGQGSEACTCDSGDYKLSLAGRRKKLFKKKYKASYVRSRSIRSVAIEVDGRVYHVGLGDAAQPRN 561

  Fly   539 FHNGNWEWWNNTDTQSGSGTFS 560
            ....:|............|.||
Human   562 LTKRHWPGAPEDQDDKDGGDFS 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7402	NP_649023.1	PRK13759	25..459	CDD:237491	103/501 (21%)
CG7402	NP_649023.1	4-S	28..436	CDD:293753	100/473 (21%)
SULF2	NP_001373981.1	G6S	43..385	CDD:293766	89/396 (22%)
		DUF3740	529..662	CDD:403667	12/55 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..588		4/24 (17%)
		ALP_like	<750..799	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740