DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7402 and GNS

DIOPT Version :9

Sequence 1:	NP_649023.1	Gene:	CG7402 / 39994	FlyBaseID:	FBgn0036768	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_002067.1	Gene:	GNS / 2799	HGNCID:	4422	Length:	552	Species:	Homo sapiens

Alignment Length:	593	Identity:	133/593 - (22%)
Similarity:	209/593 - (35%)	Gaps:	167/593 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLLVVSSILSLAYGSGYSTKPNIVIILIDDMGMNDVSFHGSNQILTP--NIDAL-AYNGILLNK 68
            |:|||:...|.:...:..:.:||:|::|.||   .|....|    :||  ...|| ...|:..:.
Human    26 LLLLVLGGCLGVFGVAAGTRRPNVVLLLTDD---QDEVLGG----MTPLKKTKALIGEMGMTFSS 83

  Fly    69 HYVPN-LCTPSRATLLTGKYPIHTGMQHFVI-------ITDEPWGLPQRERLMPEIFRD-AGYST 124
            .|||: ||.||||::|||||| |   .|.|:       .:.:.|...|.....|.|.|. .||.|
Human    84 AYVPSALCCPSRASILTGKYP-H---NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQT 144

  Fly   125 HLVGKW--HLGFWRKDLTPTMRGFDH-------------HFGYYNGYIDYYDHQVRMLDRNYSAG 174
            ...||:  ..|      .|...|.:|             :..||| |....:.:.|....|||.
Human   145 FFAGKYLNEYG------APDAGGLEHVPLGWSYWYALEKNSKYYN-YTLSINGKARKHGENYSV- 201

  Fly   175 LDFRRDLEPCPEANGTYATEAFTSEAKRIIEQHDKSKPLFMVLSHLAVHTGNEDSPMQAPEEEVA 239
                           .|.|:...:.:...::.....:|.||:::..|.|     ||..|..:...
Human   202 ---------------DYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPH-----SPWTAAPQYQK 246

  Fly   240 KFPHIRDPKRRTYA---------------------------------GMISSLDKSVAQTIGALK 271
            .|.::..|:.:.:.                                 ..:.|:|..|.:.:..|:
Human   247 AFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLE 311

  Fly   272 DNGMLNNSIILLYSDNGAPTIGIHSNAGSNYPYRGQ------KESPWEGGIRSAGALWSPLLKER 330
            ..|.|||:.|...||||..|              ||      |...:|..|:....:..|.:|.
Human   312 FTGELNNTYIFYTSDNGYHT--------------GQFSLPIDKRQLYEFDIKVPLLVRGPGIKP- 361

  Fly   331 GYVSNQAIHAVDWLPTLAGAAGVSLPQDLPLDGINLWPMLSGNEEPKPRTMIHVLDEVFGYSSYM 395
            ...|...:..:|..||:...||..| ....:||::|.|:|.|...                .::.
Human   362 NQTSKMLVANIDLGPTILDIAGYDL-NKTQMDGMSLLPILRGASN----------------LTWR 409

  Fly   396 RDTLKYVNGSSFKGRYDQWLGELETNEDDPLGESYEQHVLASDVQSLLGNRGLTKDRIRQMRSEA 460
            .|.|....|   :||          |..||...|     |:..|....      .|.:.:.....
Human   410 SDVLVEYQG---EGR----------NVTDPTCPS-----LSPGVSQCF------PDCVCEDAYNN 450

  Fly   461 TETCPPIEGQNPLESHFKCEPLKAPCF---FDLAKDPCERYNLAQ-MYPLQLQQLADELEQIRKT 521
            |..|  :...:.|.:...||......|   ::|..||.:..|:|: :.|..|.::...|..::..
Human   451 TYAC--VRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSC 513

  Fly   522 AIPSARVP 529
            :.|:.|.|
Human   514 SGPTCRTP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7402	NP_649023.1	PRK13759	25..459	CDD:237491	111/499 (22%)
CG7402	NP_649023.1	4-S	28..436	CDD:293753	108/473 (23%)
GNS	NP_002067.1	G6S	46..495	CDD:293766	122/545 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740