DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7402 and SPBPB10D8.02c

DIOPT Version :9

Sequence 1:	NP_649023.1	Gene:	CG7402 / 39994	FlyBaseID:	FBgn0036768	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_595046.1	Gene:	SPBPB10D8.02c / 2541396	PomBaseID:	SPBPB10D8.02c	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	650	Identity:	154/650 - (23%)
Similarity:	234/650 - (36%)	Gaps:	238/650 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 STKPNIVIILIDDMGMNDVSFHGSNQILTPNIDALAYNGILLNKHYVPNLCTPSRATLLTGKYPI 89
            |.|||.::|:.||:|.:|||..|| :|.||||:.||..|:.|...:..:.|:|:|:.||:|....
pombe     9 SKKPNFLVIVADDLGWSDVSPFGS-EIHTPNIERLAKEGVRLTNFHTASACSPTRSMLLSGTDNH 72

  Fly    90 HTG---MQHFVIITDEPWG--------LPQRERLMPEIFRDAGYSTHLVGKWHLGFWRKDLTPTM 143
            ..|   |...|....:.||        |..|...:|||.::|||.|.:.||||||. ..|..|:.
pombe    73 IAGLGQMAETVRRFSKVWGGKPGYEGYLNDRVAALPEILQEAGYYTTMSGKWHLGL-TPDRYPSK 136

  Fly   144 RGF----------DHHFGYYNGYID---------YYDHQVRMLD----RNYSAGLDFRRDLEPCP 185
            |||          .:||.|..|..:         .|.|....:|    :|:
pombe   137 RGFKESFALLPGGGNHFAYEPGTRENPAVPFLPPLYTHNHDPVDHKSLKNF-------------- 187

  Fly   186 EANGTYATEAFTSEAKRIIEQ---HDKSKPLFMVLSHLAVHTGNEDSPMQAPEEEVAKF------ 241
                 |::..|   |:::|:|   .:||:..|..|...|.|.     |:|:|:|.:.|:
pombe   188 -----YSSNYF---AEKLIDQLKNREKSQSFFAYLPFTAPHW-----PLQSPKEYINKYRGRYSE 239

  Fly   242 -PHIRDPKR---------------------------------------RT---YAGMISSLDKSV 263
             |.:....|                                       ||   ||.|:..||.::
pombe   240 GPDVLRKNRLQAQKDLGLIPENVIPAPVDGMGTKSWDELTTEEKEFSARTMEVYAAMVELLDLNI 304

  Fly   264 AQTIGALKDNGMLNNSIILLYSDNGA--------------PTIGIHSNAGSNY------------ 302
            .:.|..||..|.|:|:.::..|||||              |.:....|:..|.
pombe   305 GRVIDYLKTIGELDNTFVIFMSDNGAEGSVLEAIPVLSTKPPVKYFDNSLENLGNYNSFIWYGPR 369

  Fly   303 -------PYRGQKESPWEGGIRSAGALWSPLLKERGYVSNQAIHAVDWLPTLAGAAGVSLPQDLP 360
                   |.|..|....|||||....:..|.|.:...:|::.:..:|.|||:...|
pombe   370 WAQAATAPSRLSKGFITEGGIRCPAIIRYPPLIKPDIISDEFVTVMDILPTILELA--------- 425

  Fly   361 LDGINLWPMLSGNEEPKPRTMIHVLDEVFGYSSYMRDTLKYVNGSSFKGRYDQWLGELETNEDDP 425
                         |.|.|                         |..|:|| |..:         |
pombe   426 -------------EVPHP-------------------------GHKFQGR-DVVI---------P 442

  Fly   426 LGESYEQHVL-------ASDVQ--SLLGNRGLTKDRIRQMRSEATETCPPIEGQNPLESHFKCEP 481
            .|:.:..|.:       .:|..  .|.|.|.:.|...:.:       ..|.||   :::.::
pombe   443 RGKPWIDHFVHGKPVHKDTDFSGWELFGQRAIRKGNYKAI-------YVPKEG---IKTEWE--- 494

  Fly   482 LKAPCFFDLAKDPCERYNLAQMYPLQLQQLAD-----ELEQIRKTAIPSARVPHSDSRANPTFHN 541
                 .:||::|..|..|||:::|..|.:|.:     |.|....|| |...|..:.....|..||
pombe   495 -----LYDLSQDKGELENLAKVHPDILNELIEYWLVYEAETGVVTA-PDDFVAENVGLFKPAKHN 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7402	NP_649023.1	PRK13759	25..459	CDD:237491	132/561 (24%)
CG7402	NP_649023.1	4-S	28..436	CDD:293753	125/533 (23%)
SPBPB10D8.02c	NP_595046.1	AslA	8..542	CDD:225661	151/637 (24%)
SPBPB10D8.02c	NP_595046.1	PAS_like	10..508	CDD:293749	138/601 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I1617
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H73870
Inparanoid	1	1.050	111	1.000	Inparanoid score	I1569
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		otm47032
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760