DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7408 and si:dkey-174i8.1

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_021328401.1	Gene:	si:dkey-174i8.1 / 563760	ZFINID:	ZDB-GENE-160114-17	Length:	562	Species:	Danio rerio

Alignment Length:	587	Identity:	187/587 - (31%)
Similarity:	274/587 - (46%)	Gaps:	111/587 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GFVLCIALSNGIVATSDK-----PNIIIIMADDLGFDDVSFRGSNNFLTPNIDALAYSGVILNNL 76
            ||.|.:.|.:.|.....|     |:|:.:|.||.|::|:.:.|| ...||.:|.||..||.|.|.
Zfish     7 GFCLLLGLIHTIEGKVVKRGRVPPHIVFVMVDDQGYNDIGYHGS-EIQTPVLDQLAGEGVKLENY 70

  Fly    77 YVAPMCTPSRAALLTGKYPINTGMQHYVIVNDQPWGLPLNETTMAEIFRENGYRTSLLGKWHLGL 141
            ||.|:|:|||:.|:||:|.|:||:||.:|...||..||.:..|:.|..:|.||.|.::||||||.
Zfish    71 YVQPICSPSRSQLMTGRYQIHTGLQHSIIRARQPLCLPPDTPTLPERLQEAGYSTHMVGKWHLGF 135

  Fly   142 SQRNFTPTERGFDRHLGYLGAYVDYYT-QSYEQQNKGYNGHDFRDSLKSTHDHVGHYVTDLLTDA 205
            ......||.|||...||.|....|::: ||.:....  .|.|..|..:...:..|:|.|.|.|:
Zfish   136 CHPECLPTSRGFQSFLGSLTGSGDHFSFQSCDGTEA--CGFDLHDGDRPAWELRGNYSTRLYTE- 197

  Fly   206 AVKEI---EDHGSKNSSQPLFLLLNHLAPHAANDDDPMQAPAEEVSRFEYISNKTHRYYAAMVSR 267
            .||:|   .||     .:||||.:...|.|.     |:|||...:.|::.:.|:..|:||||||.
Zfish   198 RVKDILRRHDH-----RKPLFLYVALQAVHT-----PLQAPGHLLRRYQALGNRPRRHYAAMVSG 252

  Fly   268 LDKSVGSVIDALARQEMLQNSIILFLSDNGG-PTQGQHSTTASNYPLRGQKNSPWEGALRSSAAI 331
            :|:|||.::..|..:....||::::.||||| |..|     ..|:||||.|.|.|||.:|:...:
Zfish   253 VDESVGEIVSELRERGYYDNSVLIYSSDNGGQPLSG-----GCNWPLRGGKGSYWEGGVRAVGFV 312

  Fly   332 WSTEFERLGSVWKQQIYIGDLLPTLAAAAGISPDPALHLDGLNLWSALKYGYESVEREIVHVIDE 396
            .|...:|.|.|....|:|.|..|||.:.||.....:.|:||.::|..:..|......||:..||
Zfish   313 HSPLLKRKGVVSHALIHISDWYPTLLSLAGYRESDSNHVDGQDVWETISSGLPCPRTEILFNID- 376

  Fly   397 DVAEPH---------------------LSYTRGKWKVISGTTNQGLYDGWL-------GHRETSE 433
            .|:..|                     .:...|.||:::|....|   .|.       |.::...
Zfish   377 PVSRRHGDINPKLLTLNGFGIWDTGVRAAIRAGDWKLLTGNIGDG---DWFPPQTMPGGPQQWQG 438

  Fly   434 VDPRAVEYEELVRNTSVWLQLQQVSFGERNISELRDQSRIECPDPATGVKPCLPLEGPCLFDIEA 498
            ::.|..:     |..|||                                         ||:|.|
Zfish   439 MEKRRDQ-----RGKSVW-----------------------------------------LFNITA 457

  Fly   499 DPCERSNLYAEYQNSTIFLDLWSRIQQFAKQAHPPNNKPGDPNCDPRFYHNEWTWW--QDEKASS 561
            ||.||::| ||.:...:.: |.:|:.::.:.|..|.|.|.||..||:.:...||.|  |:|....
Zfish   458 DPYERADL-AEARPEVVKV-LLTRLSEYNRTAVSPRNPPDDPMADPQLHGGVWTPWLGQEEHRDE 520

  Fly   562 SG 563
            .|
Zfish   521 GG 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	148/424 (35%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	147/413 (36%)
si:dkey-174i8.1	XP_021328401.1	4-S	30..466	CDD:293753	163/505 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592861
Domainoid	1	1.000	294	0.414	Domainoid score	I1467
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2236
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm6503
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.660