DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7408 and arsj

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_688265.3	Gene:	arsj / 559800	ZFINID:	ZDB-GENE-111215-1	Length:	568	Species:	Danio rerio

Alignment Length:	612	Identity:	193/612 - (31%)
Similarity:	279/612 - (45%)	Gaps:	134/612 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTH--LDKFSSATSLLTGFVLCIALS----------NGIVATSDKPN----IIIIMADDLGFDD 49
            :|||  ::|.:...:|||.| .||..|          :.:|...||||    ||.||.||.||.|
Zfish     4 LSTHGQMEKSTFLLTLLTTF-SCIVSSTYGTWKSGFQSNLVNNMDKPNSQPHIIFIMVDDQGFRD 67

  Fly    50 VSFRGSNNFLTPNIDALAYSGVILNNLYVAPMCTPSRAALLTGKYPINTGMQHYVIVNDQPWGLP 114
            |.:.|| ...||.:|.||.:||.|.|.||.|:|:|||:.|:||:|.|:||:||.:|...||..||
Zfish    68 VGYHGS-EIKTPTLDRLAAAGVKLENYYVQPLCSPSRSQLMTGRYQIHTGLQHSIIRPTQPNCLP 131

  Fly   115 LNETTMAEIFRENGYRTSLLGKWHLGLSQRNFTPTERGFDRHLGYLGAYVDYYTQSYEQQNKGYN 179
            |...|:.:..:..||.|.::||||||..:|...||:||||...|.|....|||:. |:..:.|..
Zfish   132 LENITLPQKLKNAGYSTHMVGKWHLGFYKRACMPTQRGFDTFFGSLLGSGDYYSH-YKCDSPGLC 195

  Fly   180 GHDFRDSLKSTHDH-VGHYVTDLLTDAAVKEIEDHGSKNSSQPLFLLLNHLAPHAANDDDPMQAP 243
            |:|..:..::..:. .|.|.|.:.|..||..:..|   |..:|:||.|...|.|:     |:|.|
Zfish   196 GYDLHEGEEAAWEQDRGVYSTIMYTQKAVNILASH---NPKRPIFLYLAFQAVHS-----PLQVP 252

  Fly   244 AEEVSRFEYISNKTHRYYAAMVSRLDKSVGSVIDALARQEMLQNSIILFLSDNGG-PTQGQHSTT 307
            |..:.|::.|.|...|.||||||.||::|.::..||.:.....|.::::.||||| |..|
Zfish   253 ARYLERYKSIPNLHRRKYAAMVSCLDEAVRNLTLALKQYGYYDNMVMVYSSDNGGQPMAG----- 312

  Fly   308 ASNYPLRGQKNSPWEGALRSSAAIWSTEFERLGSVWKQQIYIGDLLPTLAAAAGISPDPALHLDG 372
            .||:||||.|.|.|||.:|:...:.|....:.|:..|..|:|.|..|||......:.|...:|||
Zfish   313 GSNWPLRGSKGSYWEGGIRAVGFVHSPLLVKKGTKSKALIHITDWYPTLVMLGEGTLDENQNLDG 377

  Fly   373 LNLWSALKYGYESVEREIVHVIDEDVAEPHLSYTR-----------------------GKWKVIS 414
            .::|.|:..|..|...:|:|.||.       .||:                       |.||:::
Zfish   378 YDVWEAISEGRPSPRLDILHNIDP-------IYTKAKNGSWKAGYGIWNTAVQAALRVGDWKLLT 435

  Fly   415 GTTNQGLYDGWL-------------GHRETSEVDPRAVEYEELVRNTSVWLQLQQVSFGERNISE 466
            |...   |..|:             .|.|....|          |..|||
Zfish   436 GVPG---YSDWIPPQTFSTLLLANRWHNERVSWD----------RGKSVW--------------- 472

  Fly   467 LRDQSRIECPDPATGVKPCLPLEGPCLFDIEADPCERSNLYAEYQNSTIFLDLWSRIQQFAKQAH 531
                                      ||:|.|||.||.:|..:|.:  :...:..::.:::|.|.
Zfish   473 --------------------------LFNITADPYERVDLSRQYPH--VVKKMLFKLLRYSKNAV 509

  Fly   532 PPNNKPGDPNCDPRFYHNEW-TWWQDE 557
            |....|.|...:|::....| .|:.|:
Zfish   510 PCRYPPKDYRSNPQYNGGVWGPWYTDD 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	154/422 (36%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	151/416 (36%)
arsj	XP_688265.3	AslA	47..501	CDD:225661	172/531 (32%)
arsj	XP_688265.3	4-S	53..487	CDD:293753	166/509 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592905
Domainoid	1	1.000	294	0.414	Domainoid score	I1467
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2236
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm6503
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.660