DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7408 and Galns

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_057931.3	Gene:	Galns / 50917	MGIID:	1355303	Length:	520	Species:	Mus musculus

Alignment Length:	551	Identity:	146/551 - (26%)
Similarity:	233/551 - (42%)	Gaps:	107/551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VLCIALSNGIVATS--DKPNIIIIMADDLGFDDVSFRGSNNFLTPNIDALAYSGVILNNLYVA-P 80
            :|.:..:.|::|..  ..|||::::.||:|:.|:...|..:..|||:|.:|..|::..:.|.| |
Mouse    10 LLLVLSALGLLAAGAPQPPNIVLLLMDDMGWGDLGVNGEPSRETPNLDRMAAEGMLFPSFYSANP 74

  Fly    81 MCTPSRAALLTGKYPINTGM-------QHYVIVNDQPWGLPLNETTMAEIFRENGYRTSLLGKWH 138
            :|:|||||||||:.||..|.       ::.....:...|:|.:|..:.|:.::.||...::||||
Mouse    75 LCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIMGGIPNSEHLLPELLKKAGYTNKIVGKWH 139

  Fly   139 LGLSQRNFTPTERGFDRHLG----YLGAY-------VDYYTQSYEQQNKGYNGHDFRDSLKSTHD 192
            || .:..|.|.:.|||...|    :.|.|       :..| :.:|...:.|  .:|..:.|:...
Mouse   140 LG-HRPQFHPLKHGFDEWFGSPNCHFGPYDNKAKPNIPVY-RDWEMVGRFY--EEFPINRKTGEA 200

  Fly   193 HVGHYVTDLLTDAAVKEIEDHGSKNSSQPLFLLLNHLAPHAANDDDPMQAPAEEVSRFEYISNKT 257
            :    :|.|.|..|:..|:...::.|  |.||.....|.||     |:.|     || :::....
Mouse   201 N----LTQLYTQEALDFIQTQHARQS--PFFLYWAIDATHA-----PVYA-----SR-QFLGTSL 248

  Fly   258 HRYYAAMVSRLDKSVGSVIDALARQEMLQNSIILFLSDNG-----GPTQGQHSTTASNYPLRGQK 317
            ...|...|..:|.|||.::..|....:.:|:.:.|.||||     .|.:|     .||.|....|
Mouse   249 RGRYGDAVREIDDSVGKILSLLQNLGISKNTFVFFTSDNGAALISAPNEG-----GSNGPFLCGK 308

  Fly   318 NSPWEGALRSSAAIWSTEFERLGSVWKQQIYIGDLLPTLAAAAGISPDPALHLDGLNLWSALKYG 382
            .:.:||.:|..|..|.......|.|..|...|.||..|..:.||:.|.....:|||:|...:..|
Mouse   309 QTTFEGGMREPAIAWWPGHIAAGQVSHQLGSIMDLFTTSLSLAGLKPPSDRVIDGLDLLPTMLKG 373

  Fly   383 YESVEREIVHVIDEDVAEPHLSYTRGKWKVISGTTNQGLYDGWLGHRETSEVDPRAVEYEELVRN 447
             :.::|.|.:.....:    ::.|.|::|....|        |..            .:||..:.
Mouse   374 -QMMDRPIFYYRGNTL----MAVTLGQYKAHLWT--------WTN------------SWEEFTQG 413

  Fly   448 TSVWLQLQQVSFGERNISELRDQSRIECPDPATGVKPCLPLEGPCLFDIEADPCERSNL---YAE 509
            |..        ...:|:|.:...::.|            ..|.|.:|.:..||.||..|   ..|
Mouse   414 TDF--------CPGQNVSGVTTHTQEE------------HTELPLIFHLGRDPGERFPLSFHSDE 458

  Fly   510 YQNSTIFLDLWSRIQQFAKQAHPPNNKPGDP 540
            ||      |..||..|.. |.|..:..||.|
Mouse   459 YQ------DALSRTTQVV-QEHQKSLVPGQP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	116/419 (28%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	116/411 (28%)
Galns	NP_057931.3	Catalytic domain. /evidence=ECO:0000250	24..377		110/379 (29%)
		GALNS	27..492	CDD:293776	143/534 (27%)
		PRK13759	28..473	CDD:237491	139/522 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740