DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7408 and ARSB

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_000037.2	Gene:	ARSB / 411	HGNCID:	714	Length:	533	Species:	Homo sapiens

Alignment Length:	566	Identity:	185/566 - (32%)
Similarity:	274/566 - (48%)	Gaps:	109/566 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VLCIALSNGIVATSDKPNIIIIMADDLGFDDVSFRGSNNFLTPNIDALAYSGVILNNLYVAPMCT 83
            :|.:|........|..|:::.::|||||::||.|.|| ...||::||||..||:|:|.|..|:||
Human    29 LLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLDALAAGGVLLDNYYTQPLCT 92

  Fly    84 PSRAALLTGKYPINTGMQHYVIVNDQPWGLPLNETTMAEIFRENGYRTSLLGKWHLGLSQRNFTP 148
            |||:.||||:|.|.||:||.:|...||..:||:|..:.::.:|.||.|.::||||||:.::...|
Human    93 PSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLP 157

  Fly   149 TERGFDRHLGYLGAYVDYYTQS----YEQQNKGYNGHDFRDSLKSTHDHVGHYVTDLLTDAAVKE 209
            |.||||.:.|||....|||:..    .:..|......||||..:....:...|.|::.|..|:..
Human   158 TRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIAL 222

  Fly   210 IEDHGSKNSSQPLFLLLNHLAPHAANDDDPMQAPAEEVSRFEYISNKTHRYYAAMVSRLDKSVGS 274
            |.:|..:   :||||.|...:.|     :|:|.|.|.:..:::|.:|...:||.|||.:|::||:
Human   223 ITNHPPE---KPLFLYLALQSVH-----EPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGN 279

  Fly   275 VIDALARQEMLQNSIILFLSDNGGPTQGQHSTTASNYPLRGQKNSPWEGALRSSAAIWSTEFERL 339
            |..||....:..|::.:|.:||||.|    ....:|:||||:|.|.|||.:|....:.|...::.
Human   280 VTAALKSSGLWNNTVFIFSTDNGGQT----LAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQK 340

  Fly   340 GSVWKQQIYIGDLLPTLAAAA-----GISPDPALHLDGLNLWSALKYGYESVEREIVHVID---- 395
            |...::.|:|.|.||||...|     |..|     |||.::|..:..|..|...|::|.||
Human   341 GVKNRELIHISDWLPTLVKLARGHTNGTKP-----LDGFDVWKTISEGSPSPRIELLHNIDPNFV 400

  Fly   396 --------------EDVAEP---------HLSYTRGKWKVISGTTNQGLYDG---WLGHRETSEV 434
                          :|.:.|         |.:...|.||:::|      |.|   |.
Human   401 DSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTG------YPGCGYWF-------- 451

  Fly   435 DPRAVEYEELVRNTSVWLQLQQVSFGERNISELRDQSRIECPDPATGVKPCLPLEGPCLFDIEAD 499
             |...:|                     |:||      |...||        |.:...||||:.|
Human   452 -PPPSQY---------------------NVSE------IPSSDP--------PTKTLWLFDIDRD 480

  Fly   500 PCERSNLYAEYQNSTIFLDLWSRIQQFAKQAHPPNNKPGDPNCDPR 545
            |.||.:|..||.:  |...|.||:|.:.|.:.|......||.|||:
Human   481 PEERHDLSREYPH--IVTKLLSRLQFYHKHSVPVYFPAQDPRCDPK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	150/432 (35%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	147/423 (35%)
ARSB	NP_000037.2	AslA	41..489	CDD:225661	169/515 (33%)
ARSB	NP_000037.2	4-S	45..488	CDD:293753	167/510 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157200
Domainoid	1	1.000	290	1.000	Domainoid score	I1555
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2283
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8485
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.660