DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7408 and ARSA

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_016884289.1	Gene:	ARSA / 410	HGNCID:	713	Length:	547	Species:	Homo sapiens

Alignment Length:	608	Identity:	174/608 - (28%)
Similarity:	240/608 - (39%)	Gaps:	162/608 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LCIALSNGIVATSDKPNIIIIMADDLGFDDVSFRGSNNFLTPNIDALAYSGVILNNLYV-APMCT 83
            |.:||:.|: |.:..|||::|.|||||:.|:...|..:..|||:|.||..|:...:.|| ..:||
Human     9 LLLALAAGL-AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCT 72

  Fly    84 PSRAALLTGKYPINTGMQHYVIVNDQPWGLPLNETTMAEIFRENGYRTSLLGKWHLGLSQRN-FT 147
            |||||||||:.|:..||...|:|.....||||.|.|:||:....||.|.:.||||||:.... |.
Human    73 PSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFL 137

  Fly   148 PTERGFDRHLGYLGAYVDYYTQSYEQ---QNKGYNGHDFRDSLKSTHDHVGHYVTDLLTDAAVKE 209
            |..:||.|.||     :.|   |::|   ||                          ||......
Human   138 PPHQGFHRFLG-----IPY---SHDQGPCQN--------------------------LTCFPPAT 168

  Fly   210 IEDHGSKNSSQPLFLLLNHLAPHA---------------ANDDDPMQAPAEEVSR---FEYISNK 256
            ..|.|......|:.||.| |:..|               |:|   :.|.|:...|   ..|.|:.
Human   169 PCDGGCDQGLVPIPLLAN-LSVEAQPPWLPGLEARYMAFAHD---LMADAQRQDRPFFLYYASHH 229

  Fly   257 TH------RYYAAMVSR---------LDKSVGSVIDALARQEMLQNSIILFLSDNGGPTQGQHST 306
            ||      :.:|....|         ||.:||:::.|:....:|:.::::|.:|||..|......
Human   230 THYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRG 294

  Fly   307 TASNYPLRGQKNSPWEGALRSSA-AIW------STEFERLGSVWKQQIYIGDLLPTLAAAAGISP 364
            ..|.. ||..|.:.:||.:|..| |.|      ....|...|:        ||||||||.|| :|
Human   295 GCSGL-LRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSL--------DLLPTLAALAG-AP 349

  Fly   365 DPALHLDGLNLWSALKYG-----------YESVEREIVHVIDEDVAEPHLSYTRGKWKVISGTTN 418
            .|.:.|||.:| |.|..|           |.|...|:..|         .:...||:|....|
Human   350 LPNVTLDGFDL-SPLLLGTGKSPRQSLFFYPSYPDEVRGV---------FAVRTGKYKAHFFT-- 402

  Fly   419 QGLYDGWLGHRE--TSEVDPRAVE-------YEELVRNTSVWLQLQQVSFGERNISELRDQSRIE 474
            ||....|:...:  |....||::.       ..||..:..               |...|.:
Human   403 QGNPSPWIPPPDLLTPPRSPRSLAPPLALALCTELAPSPG---------------SAHSDTT--- 449

  Fly   475 CPDPATGVKPCLPL-EGPCLFDIEADPCERSNLYAEYQNST-IFLDLWSRIQ------------- 524
             .|||......|.. |.|.|:|:..||.|..||......:| ..|....::|
Human   450 -ADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFG 513

  Fly   525 --QFAKQAHPPNNKPGDPNCDPR 545
              |.|:...|.......|.|.||
Human   514 PSQVARGEDPALQICCHPGCTPR 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	138/449 (31%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	138/443 (31%)
ARSA	XP_016884289.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157185
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740