Protein Alignment CG7408 and IDS

DIOPT Version :10

• Sequence 1: NP_649020.1
• Gene: CG7408 / 39991
• FlyBaseID: FBgn0036765
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_000193.1
• Gene: IDS / 3423
• HGNCID: 5389
• Length: 550
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 138/629 - (21%)
• Similarity: 224/629 - (35%)
• Gaps: 220/629 - (34%)

  Fly    14 LLTGFVL---CIALSNGIVA--TSDKPNIIIIMADDLGFDDVSFRGSNNFLTPNIDALAYSGVIL 73
            |..|.||   |:||.:...|  |:|..|:::|:.|||. ..:...|.....:||||.||...::.
Human    11 LWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLF 74

  Fly    74 NNLYV-APMCTPSRAALLTGKYPINTGMQHYVIVNDQPWGLPL-NETTMAEIFRENGYRTSLLGK 136
            .|.:. ..:|.|||.:.|||:.|..|.:..:    :..|.:.. |.:|:.:.|:||||.|..:||
Human    75 QNAFAQQAVCAPSRVSFLTGRRPDTTRLYDF----NSYWRVHAGNFSTIPQYFKENGYVTMSVGK 135

  Fly   137 -WHLGLSQRNFTPTERGFDRHLGYLGAYVDYYTQSYEQQN-KGYNGHDFRDSLKSTHDHVGHYVT 199
             :|.|:|..:...:.        |..::..|:..|.:.:| |...|.|            |....
Human   136 VFHPGISSNHTDDSP--------YSWSFPPYHPSSEKYENTKTCRGPD------------GELHA 180

  Fly   200 DLL------------------TDAAVKEIEDHGSKNSSQPLFLLLNHLAPH-------------- 232
            :||                  |:.|::.:|.  .|.|:.|.||.:.:..||
Human   181 NLLCPVDVLDVPEGTLPDKQSTEQAIQLLEK--MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYP 243

  Fly   233 ------AANDDDPMQAP------------AEEVSRFEY----------ISNKTHRYYAAMVSRLD 269
                  |.:.:.|...|            .|:|.....          ...|..:.|.|.||.||
Human   244 LENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLD 308

  Fly   270 KSVGSVIDALARQEMLQNSIILFLSDNGGPTQGQHSTTA--SNY-------------------PL 313
            ..||.::.||...::..::||.|.||:|. ..|:|...|  ||:                   |.
Human   309 TQVGRLLSALDDLQLANSTIIAFTSDHGW-ALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPE 372

  Fly   314 RGQKNSPWEGALRSSAAIWSTEFERLGSVWKQQIYIGDLLPTLAAAAGIS-----PDPALHL--- 370
            .|:|..|:.....|::.:...     |......:.:..|.||||..||:.     |.|:.|:
Human   373 AGEKLFPYLDPFDSASQLMEP-----GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELC 432

  Fly   371 -DGLNLWSALKYGYESVEREIVHVIDEDVAEPHL-----------SYTR----GKW--------- 410
             :|.||....::      |:    ::||   |:|           .|.|    .:|
Human   433 REGKNLLKHFRF------RD----LEED---PYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKD 484

  Fly   411 -KVI--SGTTNQGLYDGWLGHRETSEVDPRAVEYEELVRNTSVWLQLQQVSFGERNISELRDQSR 472
             |::  |..|....|..|:|...           :|.:.|.|      .:..||
Human   485 IKIMGYSIRTIDYRYTVWVGFNP-----------DEFLANFS------DIHAGE----------- 521

  Fly   473 IECPDPATGVKPCLPLEGPCLFDIEADPCERSNLYAEYQNSTIF 516
                                |:.:::||.:..|:|.:.|...:|
Human   522 --------------------LYFVDSDPLQDHNMYNDSQGGDLF 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_649020.1	4-S	35..423	CDD:293753	113/508 (22%)
IDS	NP_000193.1	iduronate-2-sulfatase	38..540	CDD:293754	126/595 (21%)