DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7408 and ARSI

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001012301.1	Gene:	ARSI / 340075	HGNCID:	32521	Length:	569	Species:	Homo sapiens

Alignment Length:	590	Identity:	185/590 - (31%)
Similarity:	267/590 - (45%)	Gaps:	111/590 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LTGFVLCIALSNGIV-----------------------ATSDKPNIIIIMADDLGFDDVSFRGSN 56
            ||||.|...||.|.:                       |....|:||.|:.||.|:.||.:.||
Human     4 LTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGS- 67

  Fly    57 NFLTPNIDALAYSGVILNNLYVAPMCTPSRAALLTGKYPINTGMQHYVIVNDQPWGLPLNETTMA 121
            :..||.:|.||..||.|.|.|:.|:|||||:.||||:|.|:||:||.:|...||..|||::.|:.
Human    68 DIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLP 132

  Fly   122 EIFRENGYRTSLLGKWHLGLSQRNFTPTERGFDRHLGYLGAYVDYYTQSYEQ-QNKGYNGHDFRD 185
            :..:|.||.|.::||||||..::...||.||||..||.|...|||||  |:. ...|..|.|..:
Human   133 QKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYT--YDNCDGPGVCGFDLHE 195

  Fly   186 SLKSTHDHVGHYVTDLLTDAAVKEIEDHGSKNSSQPLFLLLNHLAPHAANDDDPMQAPAEEVSRF 250
            .........|.|.|.|....|...:..|   :..:||||.:...|.|.     |:|:|.|.:.|:
Human   196 GENVAWGLSGQYSTMLYAQRASHILASH---SPQRPLFLYVAFQAVHT-----PLQSPREYLYRY 252

  Fly   251 EYISNKTHRYYAAMVSRLDKSVGSVIDALARQEMLQNSIILFLSDNGGPTQGQHSTTASNYPLRG 315
            ..:.|...|.|||||:.:|::|.::..||.|.....||:|:|.|||||.|    .:..||:||||
Human   253 RTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQT----FSGGSNWPLRG 313

  Fly   316 QKNSPWEGALRSSAAIWSTEFERLGSVWKQQIYIGDLLPTLAAAAGISPDPALHLDGLNLWSALK 380
            :|.:.|||.:|....:.|...:|.....:..::|.|..|||...||.:...|..|||.::|.|:.
Human   314 RKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAIS 378

  Fly   381 YGYESVEREIVHVIDEDVAEPHLSYTR---------------------GKWKVISGTTNQGLYDG 424
            .|..|...||:|.||     |..::.:                     |:||:::|...   |..
Human   379 EGRASPRTEILHNID-----PLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPG---YGD 435

  Fly   425 WLGHRETSEVDPRAVEYEELVRNTSVWLQLQQVSFGERNISELRDQSRIECPDPATGVKPCLPLE 489
            |        :.|     :.|......|..|::::...:.:
Human   436 W--------IPP-----QTLATFPGSWWNLERMASVRQAV------------------------- 462

  Fly   490 GPCLFDIEADPCERSNLYAEYQNSTIFLDLWSRIQQFAKQAHPPNNKPGDPNCDPRFYHNEW-TW 553
              .||:|.|||.||.:|..  |...:...|.:|:.::.:.|.|......:|...|.|....| .|
Human   463 --WLFNISADPYEREDLAG--QRPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPW 523

  Fly   554 WQDEK 558
            ..||:
Human   524 ASDEE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	150/415 (36%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	149/409 (36%)
ARSI	NP_001012301.1	4-S	48..478	CDD:293753	162/492 (33%)
ARSI	NP_001012301.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..539		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157149
Domainoid	1	1.000	290	1.000	Domainoid score	I1555
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H44428
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2283
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8485
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.660