DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7408 and Arsi

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001041346.1	Gene:	Arsi / 307404	RGDID:	1310242	Length:	573	Species:	Rattus norvegicus

Alignment Length:	605	Identity:	188/605 - (31%)
Similarity:	273/605 - (45%)	Gaps:	113/605 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LTGFVLCIALSNGIV-----------------------ATSDKPNIIIIMADDLGFDDVSFRGSN 56
            |:||.|...||.|.:                       |....|:||.|:.||.|:.||.:.||
  Rat     4 LSGFSLVSLLSLGYLSWDWAKPGLVADGPAEAEDQPSAAPPQPPHIIFILTDDQGYHDVGYHGS- 67

  Fly    57 NFLTPNIDALAYSGVILNNLYVAPMCTPSRAALLTGKYPINTGMQHYVIVNDQPWGLPLNETTMA 121
            :..||.:|.||..||.|.|.|:.|:|||||:.||||:|.|:||:||.:|...||..|||::.|:.
  Rat    68 DIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQVTLP 132

  Fly   122 EIFRENGYRTSLLGKWHLGLSQRNFTPTERGFDRHLGYLGAYVDYYTQSYEQ-QNKGYNGHDFRD 185
            :..:|.||.|.::||||||..::...||.||||..||.|...|||||  |:. ...|..|.|..:
  Rat   133 QKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYT--YDNCDGPGVCGFDLHE 195

  Fly   186 SLKSTHDHVGHYVTDLLTDAAVKEIEDHGSKNSSQPLFLLLNHLAPHAANDDDPMQAPAEEVSRF 250
            .........|.|.|.|....|...:..|   :..:||||.:...|.|.     |:|:|.|.:.|:
  Rat   196 GESVAWGLSGQYSTMLYAQRASHILASH---SPQKPLFLYVAFQAVHT-----PLQSPREYLYRY 252

  Fly   251 EYISNKTHRYYAAMVSRLDKSVGSVIDALARQEMLQNSIILFLSDNGGPTQGQHSTTASNYPLRG 315
            ..:.|...|.|||||:.:|::|.::..||.|.....||:|:|.|||||.|    .:..||:||||
  Rat   253 RTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQT----FSGGSNWPLRG 313

  Fly   316 QKNSPWEGALRSSAAIWSTEFERLGSVWKQQIYIGDLLPTLAAAAGISPDPALHLDGLNLWSALK 380
            :|.:.|||.:|....:.|...::.....:..::|.|..|||...||.:...|..|||.::|.|:.
  Rat   314 RKGTYWEGGVRGLGFVHSPLLKKKRRTSRALVHITDWYPTLVGLAGGTTSAADGLDGYDVWPAIS 378

  Fly   381 YGYESVEREIVHVIDEDVAEPHLSYTR---------------------GKWKVISGTTNQGLYDG 424
            .|..|...||:|.||     |..::.|                     |:||:::|...   |..
  Rat   379 EGRASPRTEILHNID-----PLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPG---YGD 435

  Fly   425 WLGHRETSEVDPRAVEYEELVRNTSVWLQLQQVSFGERNISELRDQSRIECPDPATGVKPCLPLE 489
            |        :.|     :.|......|..|::       ::.:|                    :
  Rat   436 W--------IPP-----QTLASFPGSWWNLER-------MASIR--------------------Q 460

  Fly   490 GPCLFDIEADPCERSNLYAEYQNSTIFLDLWSRIQQFAKQAHPPNNKPGDPNCDPRFYHNEWTWW 554
            ...||:|.|||.||.:| |: |...:...|.:|:..:.:.|.|......:|...|.|....|..|
  Rat   461 AVWLFNISADPYEREDL-AD-QRPDVVRTLLARLADYNRTAIPVRYPAANPRAHPDFNGGAWGPW 523

  Fly   555 ---QDEKASSSGTIGVMKVF 571
               :||:.......|..:.|
  Rat   524 ASDEDEEEEDEEEEGRARSF 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	150/415 (36%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	149/409 (36%)
Arsi	NP_001041346.1	4-S	48..478	CDD:293753	164/493 (33%)
		AslA	49..485	CDD:225661	166/500 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..550		9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351113
Domainoid	1	1.000	308	1.000	Domainoid score	I1294
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H44428
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8957
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.660