DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7408 and GNS

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_002067.1	Gene:	GNS / 2799	HGNCID:	4422	Length:	552	Species:	Homo sapiens

Alignment Length:	600	Identity:	136/600 - (22%)
Similarity:	226/600 - (37%)	Gaps:	191/600 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HLDKFSSATSLLTGFVL--CIALSNGIVATSDKPNIIIIMADDLGFDDVSFRGSNNFLTPNIDAL 66
            ||...|.|..||   ||  |:.:. |:.|.:.:||:::::.||.  |:|  .|....|......:
Human    18 HLPSCSPALLLL---VLGGCLGVF-GVAAGTRRPNVVLLLTDDQ--DEV--LGGMTPLKKTKALI 74

  Fly    67 AYSGVILNNLYV-APMCTPSRAALLTGKYPINTGMQHYVIVN-------DQPWGLPLNETTMAEI 123
            ...|:..::.|| :.:|.||||::||||||.|    |:|:.|       .:.|.......|...|
Human    75 GEMGMTFSSAYVPSALCCPSRASILTGKYPHN----HHVVNNTLEGNCSSKSWQKIQEPNTFPAI 135

  Fly   124 FREN-GYRTSLLGKWHLGLSQRNFTPTERGFDR-HLGYLGAYVDYYTQSYEQQNKGYNGHDFRDS 186
            .|.. ||:|...||:   |::.. .|...|.:. .||:      .|..:.|:.:|.||   :..|
Human   136 LRSMCGYQTFFAGKY---LNEYG-APDAGGLEHVPLGW------SYWYALEKNSKYYN---YTLS 187

  Fly   187 LK-STHDHVGHYVTDLLTDAAVK---EIEDHGSKNSSQPLFLLLNHLAPHAANDDDPMQ------ 241
            :. ....|..:|..|.|||....   :..|:  |::.:|.|:::...|||:.....|..
Human   188 INGKARKHGENYSVDYLTDVLANVSLDFLDY--KSNFEPFFMMIATPAPHSPWTAAPQYQKAFQN 250

  Fly   242 --APAEE---------------------VSRFEYISNKTHRYYAAMVSRLDKSVGSVIDALARQE 283
              ||..:                     .|..:::.|...:.:..::| :|..|..::..|....
Human   251 VFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTG 314

  Fly   284 MLQNSIILFLSDNGGPTQGQHSTTASNYPLRGQKNSPWEGALRSSAAIWSTEFERLGSVWKQQIY 348
            .|.|:.|.:.||||..|              ||.:.|                     :.|:|:|
Human   315 ELNNTYIFYTSDNGYHT--------------GQFSLP---------------------IDKRQLY 344

  Fly   349 IGDL-LPTLAAAAGISPDPALHLDGLNLWSALKYGYESVEREIVHVID-----EDVAEPHLSYTR 407
            ..|: :|.|....||.|:                   ...:.:|..||     .|:|...|:.|:
Human   345 EFDIKVPLLVRGPGIKPN-------------------QTSKMLVANIDLGPTILDIAGYDLNKTQ 390

  Fly   408 ----GKWKVISGTTNQGLYDGWLGHRETSEVDPRAVEYEELVRNTSVWLQLQQVSFGE-RNISEL 467
                ....::.|.:|.    .|     .|:|   .|||:                 || ||:::
Human   391 MDGMSLLPILRGASNL----TW-----RSDV---LVEYQ-----------------GEGRNVTD- 425

  Fly   468 RDQSRIECPDPATGVKPCLPLEGPCLFDIEAD---PCERS-----NL-YAEYQNSTIFLDLWS-- 521
                 ..||..:.||..|.|   .|:.:...:   .|.|:     || |.|:.:..:|:::::
Human   426 -----PTCPSLSPGVSQCFP---DCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLT 482

  Fly   522 ----RIQQFAKQAHP 532
                :|...||...|
Human   483 ADPDQITNIAKTIDP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	97/446 (22%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	97/440 (22%)
GNS	NP_002067.1	G6S	46..495	CDD:293766	124/564 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740