DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7408 and Arsb

DIOPT Version :9

Sequence 1:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_033842.3	Gene:	Arsb / 11881	MGIID:	88075	Length:	534	Species:	Mus musculus

Alignment Length:	572	Identity:	187/572 - (32%)
Similarity:	287/572 - (50%)	Gaps:	95/572 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLTGFVLCIALSNGIVATSDKPNIIIIMADDLGFDDVSFRGSNNFLTPNIDALAYSGVILNNLYV 78
            ||...:|.::.:....|| ..|:::.::|||||::|:.|.|| ...||::||||..||:|:|.||
Mouse    26 LLQLLLLLLSPARASGAT-QPPHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYV 88

  Fly    79 APMCTPSRAALLTGKYPINTGMQHYVIVNDQPWGLPLNETTMAEIFRENGYRTSLLGKWHLGLSQ 143
            .|:|||||:.||||:|.|:.|:|||:|:..||..:||:|..:.::.:|.||.|.::||||||:.:
Mouse    89 QPLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSCVPLDEKLLPQLLKEAGYATHMVGKWHLGMYR 153

  Fly   144 RNFTPTERGFDRHLGYLGAYVDYYTQSYEQQNKGYNGH----DFRDSLKSTHDHVGHYVTDLLTD 204
            :...||.||||.:.|||....||||.......:..||.    |.||..:...::...|.|::.|.
Mouse   154 KECLPTRRGFDTYFGYLLGSEDYYTHEACAPIESLNGTRCALDLRDGEEPAKEYNNIYSTNIFTK 218

  Fly   205 AAVKEIEDHGSKNSSQPLFLLLNHLAPHAANDDDPMQAPAEEVSRFEYISNKTHRYYAAMVSRLD 269
            .|...|.:|..:   :||||.|...:.|     ||:|.|.|.:..:.:|.:|..|.||.|||.:|
Mouse   219 RATTVIANHPPE---KPLFLYLAFQSVH-----DPLQVPEEYMEPYGFIQDKHRRIYAGMVSLMD 275

  Fly   270 KSVGSVIDALARQEMLQNSIILFLSDNGGPTQGQHSTTASNYPLRGQKNSPWEGALRSSAAIWST 334
            ::||:|..||....:..|::.:|.:||||.|:    :..:|:||||:|.:.|||.:|.:..:.|.
Mouse   276 EAVGNVTKALKSHGLWNNTVFIFSTDNGGQTR----SGGNNWPLRGRKGTLWEGGIRGTGFVASP 336

  Fly   335 EFERLGSVWKQQIYIGDLLPTLAAAAGISPDPALHLDGLNLWSALKYGYESVEREIVHVIDEDVA 399
            ..::.|...::.::|.|.||||...||.|.:....|||.|:|..:..|:.|...|::|.||:|..
Mouse   337 LLKQKGVKSRELMHITDWLPTLVDLAGGSTNGTKPLDGFNMWKTISEGHPSPRVELLHNIDQDFF 401

  Fly   400 E----PHLSYTRGK-----------------------WKVISGTTNQGLYDGWLGHRETSEVDPR 437
            :    |..:.|..|                       ||:::|....|
Mouse   402 DGLPCPGKNMTPAKDDSFPLEHSAFNTSIHAGIRYKNWKLLTGHPGCG----------------- 449

  Fly   438 AVEYEELVRNTSVWLQLQQVSFGERNISELRDQSRIECPDPATGVKPCLPLEGPCLFDIEADPCE 502
                        .|......|    |:||      |...||        |.:...||||..||.|
Mouse   450 ------------YWFPPPSQS----NVSE------IPPVDP--------PTKTLWLFDINQDPEE 484

  Fly   503 RSNLYAEYQNSTIFLDLWSRIQQFAKQAHPPNNKPGDPNCDPRFYHNEWTWW 554
            |.::..|:.:  |..:|.||:|.:.:.:.|.:..|.||.|||: ....|:.|
Mouse   485 RHDVSREHPH--IVQNLLSRLQYYHEHSVPSHFPPLDPRCDPK-STGVWSPW 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	151/424 (36%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	150/418 (36%)
Arsb	NP_033842.3	AslA	42..490	CDD:225661	169/508 (33%)
Arsb	NP_033842.3	4-S	46..489	CDD:293753	167/502 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847587
Domainoid	1	1.000	307	1.000	Domainoid score	I1340
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2247
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8720
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.660