DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5535 and SAM3

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_015049.1	Gene:	SAM3 / 855854	SGDID:	S000006195	Length:	587	Species:	Saccharomyces cerevisiae

Alignment Length:	605	Identity:	133/605 - (21%)
Similarity:	222/605 - (36%)	Gaps:	178/605 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEDSNES-------KLA-----KVLSAFDLTALGIGSTLGVGVYVLAGEVSKQY---AGP-AVVV 76
            ||:|.::       |||     ||||...||.:.||.|||.|:::..|     |   :|| |:::
Yeast    53 LENSEQTEQEKIQWKLASQPYQKVLSQRHLTMIAIGGTLGTGLFIGLG-----YSLASGPAALLI 112

  Fly    77 SFLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLS 141
            .||:...:........||...:.|.:||...:....|.|.:.|.:..|..|.:.|...|.:.|.:
Yeast   113 GFLLVGTSMFCVVQSAAELSCQFPVSGSYATHVSRFIDESVGFTVATNYALAWLISFPSELIGCA 177

  Fly   142 ---TYLDQLCGNP---MSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVF 200
               :|.:|.. ||   ::.|....|.||:.|:..:.:. .|.::|:..:||             |
Yeast   178 LTISYWNQTV-NPAVWVAIFYVFIMVLNLFGVRGFAET-EFALSIIKVIAI-------------F 227

  Fly   201 TMLNLGVVLFVIIAG-----LFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFI 260
            ..:.:|:||   |||     ...:.:..|..|          |.|.......:........:.|.
Yeast   228 IFIIIGIVL---IAGGGPNSTGYIGAKYWHDP----------GAFAKPVFKNLCNTFVSAAFSFG 279

  Fly   261 GFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGW 325
            |.:.:.....|:|| ..:|..|...:...|.:.|.....::..::||.:
Yeast   280 GSELVLLTSTESKN-ISAISRAAKGTFWRIAIFYITTVVIIGCLVPYND---------------- 327

  Fly   326 HVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTG 390
                                      ||::...:::        |:|   .:||   :|....||
Yeast   328 --------------------------PRLLSGSNSE--------DVS---ASPF---VIALSNTG 352

  Fly   391 ILAAVFNLSQLVNMMSIGTLLA-YSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRP--CAL 452
            .:.|     ::.|.|::..|:| .|:..|||.         ..||::   :|.|.....|  |:.
Yeast   353 SMGA-----KVSNFMNVVILVAVVSVCNSCVY---------ASSRLI---QALGASGQLPSVCSY 400

  Fly   453 WRR------------IFNLNGQTVPTKQTSRIVTY-----SVTLFSLW-CMVFSQILTKFEEDL- 498
            ..|            .|.|.|..|.:|:...:.|:     |::.|..| |:..|||  :|...|
Yeast   401 MDRKGRPLVGIGISGAFGLLGFLVASKKEDEVFTWLFALCSISSFFTWFCICMSQI--RFRMALK 463

  Fly   499 ANVTSFDGIKL---------VLGTIPLAVLL---LVISRQPT---SGVKLSFKVPLVPWLPGISI 548
            |...|.|.|..         :||.:..|:|:   :.:|..|.   |..:..|:..|     .|.|
Yeast   464 AQGRSNDEIAYKSILGVYGGILGCVLNALLIAGEIYVSAAPVGSPSSAEAFFEYCL-----SIPI 523

  Fly   549 LINIYLMIKLDILTWIRFSI 568
            :|.:|...:.....|..|.|
Yeast   524 MIVVYFAHRFYRRDWKHFYI 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	133/605 (22%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	9/34 (26%)
SAM3	NP_015049.1	2A0310	74..551	CDD:273334	127/584 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345693
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.800