DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and LYP1

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_014131.1	Gene:	LYP1 / 855453	SGDID:	S000005212	Length:	611	Species:	Saccharomyces cerevisiae

Alignment Length:	467	Identity:	87/467 - (18%)
Similarity:	192/467 - (41%)	Gaps:	80/467 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SVTNAFRVLTRKKPL-------EDSNES-----KLAKVLSAFDLTALGIGSTLGVGVYV-LAGEV 65
            |:||:   |||.:.:       ||..|:     .:.:.|....:..:.:|.|:|.|::| ::..:
Yeast    75 SITNS---LTRLQVVSHETDINEDEEEAHYEDKHVKRALKQRHIGMIALGGTIGTGLFVGISTPL 136

  Fly    66 SKQYAGP-AVVVSFLIAAIASIFAGLCYAEFGARVPKAGSAYIYS----YVTIGEFIAFLIGWNL 125
            |.  ||| ..:::::.......|......|....:|...|..::|    ....|....::..:|.
Yeast   137 SN--AGPVGSLIAYIFMGTIVYFVTQSLGEMATFIPVTSSITVFSKRFLSPAFGVSNGYMYWFNW 199

  Fly   126 ILEYAIGSASVVKGLSTYLDQLCGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGA 190
            .:.||:..:.:.:.:..:.|::   |:::::.               :|..::|::....:.|..
Yeast   200 AITYAVEVSVIGQVIEYWTDKV---PLAAWIA---------------IFWVIITLMNFFPVKVYG 246

  Fly   191 KESTRVNNVFTMLNLGVVLF--VIIAG---LFKVSSSNWSIPKSQVP----EGYGDGGFMPYGVS 246
            :....|.:|..:..:|.:::  :|:.|   ...:....|..|.:..|    ....:|.|:.: ||
Yeast   247 EFEFWVASVKVLAIMGYLIYALIIVCGGSHQGPIGFRYWRNPGAWGPGIISSDKSEGRFLGW-VS 310

  Fly   247 GIIKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQD 311
            .:|..|    :.:.|.:.:.....||.||:|::|.|:...:..|.|.|......:.:::||  .|
Yeast   311 SLINAA----FTYQGTELVGITAGEAANPRKTVPRAINKVVFRIVLFYIMSLFFIGLLVPY--ND 369

  Fly   312 EK--------APLPHVFRIN--GWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFK 366
            .:        |..|.|..|.  |.:....:.:...:..:.|:....::...|::::::..|...|
Yeast   370 SRLSASSAVIASSPFVISIQNAGTYALPDIFNAVVLITVVSAANSNVYVGSRVLYSLARTGNAPK 434

  Fly   367 FLGDISEKYKTPFKGTMITGMLTGILA---------AVFNLSQLVNMMSIGTLLAYSMVASCVLM 422
            ..|.:: :...|:.|.:.|..| |:||         ..||  .|:|:.::..|.|:..::...:.
Yeast   435 QFGYVT-RQGVPYLGVVCTAAL-GLLAFLVVNNNANTAFN--WLINISTLAGLCAWLFISLAHIR 495

  Fly   423 LRYEVDDRRESR 434
            ....:..|..||
Yeast   496 FMQALKHRGISR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	84/461 (18%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
LYP1	NP_014131.1	2A0310	107..583	CDD:273334	78/432 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960