DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and GAP1

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_012965.3	Gene:	GAP1 / 853912	SGDID:	S000001747	Length:	602	Species:	Saccharomyces cerevisiae

Alignment Length:	497	Identity:	110/497 - (22%)
Similarity:	181/497 - (36%)	Gaps:	115/497 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RKKPLE-DSNESKLAKV------------LSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVV 75
            |.||:| |.|.|:..||            |....|..:.||..:|.|:.|.:| .:.:..|||
Yeast    61 RVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSG-TALRTGGPA-- 122

  Fly    76 VSFLI---AAIASIFA-GLCYAEFGARVPKAGSAYIYSYVTIGEFIA------FLIGWNLILEYA 130
             |.||   :....|:| .:...|.....|.:|....|:...|.|...      :::.|.::|...
Yeast   123 -SLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLE 186

  Fly   131 IGSASVVKGLSTYLDQLCGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAV----GAK 191
            |.|||:.               .:|.||.        ..|.|.|    ..||.|||.:    |.|
Yeast   187 IVSASIT---------------VNFWGTD--------PKYRDGF----VALFWLAIVIINMFGVK 224

  Fly   192 ESTRVNNVFTMLNLGVVLFVIIAGLF----------KVSSSNWSIPKSQVPEGYGDGGFMPYGVS 246
            .......||:.:.:..|:..||.|:.          .:....|..|          |.|......
Yeast   225 GYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDP----------GAFAGDTPG 279

  Fly   247 GIIKGAAVCF----YGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPY 307
            ...||....|    :.|.|.:.:..|..|:..|:||:|.|.......|.|.|.....::.:::||
Yeast   280 AKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPY 344

  Fly   308 FEQD-------EKAPLPHVFRI--NGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGL 363
            .::.       :.|..|.|..|  :|......||::..:..:.|....|::...|.:.|::....
Yeast   345 NDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRF 409

  Fly   364 LFKFLGDISEKYKTPFKGTMIT---GMLTGILAA-----VFNLSQLVNMMSIGTLLAYSMVASCV 420
            |.:....:..|.: |..|..:|   |::..:.|:     |||  .|:.:..:.:|..:..:..|.
Yeast   410 LPEIFSYVDRKGR-PLVGIAVTSAFGLIAFVAASKKEGEVFN--WLLALSGLSSLFTWGGICICH 471

  Fly   421 LMLRYEVDDRRESRIVANGRATGLEQ---DRPCALWRRIFNL 459
            :..|        ..:.|.||  ||::   ..|..:|...:.|
Yeast   472 IRFR--------KALAAQGR--GLDELSFKSPTGVWGSYWGL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	110/497 (22%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
GAP1	NP_012965.3	LysP	43..601	CDD:223903	110/497 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
TreeFam	0	0.000	Not matched by this tool.
	5	4.990