DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and HIP1

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_011707.1	Gene:	HIP1 / 853104	SGDID:	S000003423	Length:	603	Species:	Saccharomyces cerevisiae

Alignment Length:	434	Identity:	102/434 - (23%)
Similarity:	183/434 - (42%)	Gaps:	90/434 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EDSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPA-VVVSFLIAAIASIFAGLCY 92
            ||.|.:.|:|.||...|..|.:|..:|.|:||..| .:....||| :|:.::|.:..........
Yeast    79 EDINNTNLSKDLSVRHLLTLAVGGAIGTGLYVNTG-AALSTGGPASLVIDWVIISTCLFTVINSL 142

  Fly    93 AEFGARVPKAGSAYIYSYVTIGEFIAFLIG------WNLILEYAIGSASVVKGLSTYLDQLCGNP 151
            .|..|..|..|...:||...|....||.:.      |.::|...:.:||:.  :..:.|::..:.
Yeast   143 GELSAAFPVVGGFNVYSMRFIEPSFAFAVNLNYLAQWLVLLPLELVAASIT--IKYWNDKINSDA 205

  Fly   152 -MSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFV---- 211
             ::.|..|....|:..:.::.:. .||::::..|:| :|          ||:  ||:||..
Yeast   206 WVAIFYATIALANMLDVKSFGET-EFVLSMIKILSI-IG----------FTI--LGIVLSCGGGP 256

  Fly   212 ---IIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCF----YGFIGFDCIATAG 269
               .|.|.:      |..|          |.|:.:......||....|    :.:.|.:..|.:.
Yeast   257 HGGYIGGKY------WHDP----------GAFVGHSSGTQFKGLCSVFVTAAFSYSGIEMTAVSA 305

  Fly   270 EEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAE----- 329
            .|:|||:::||.|...:..:|..:|..:.|::..::|  ..|.:.       :||....:
Yeast   306 AESKNPRETIPKAAKRTFWLITASYVTILTLIGCLVP--SNDPRL-------LNGSSSVDAASSP 361

  Fly   330 YVVSI--GAMFGLCSSM------------MGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFK 380
            .|::|  |.:.||.|.|            ..|::...|.:.||::.|.|.|||..: :|...|..
Yeast   362 LVIAIENGGIKGLPSLMNAIILIAVVSVANSAVYACSRCMVAMAHIGNLPKFLNRV-DKRGRPMN 425

  Fly   381 GTMIT---GMLTGILAA-----VFN-LSQLVNMMSIGTLLAYSM 415
            ..::|   |:|:.:.|:     ||. ||.|..:.:|...:|.::
Yeast   426 AILLTLFFGLLSFVAASDKQAEVFTWLSALSGLSTIFCWMAINL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	102/434 (24%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
HIP1	NP_011707.1	2A0310	88..567	CDD:273334	98/425 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46729
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
TreeFam	0	0.000	Not matched by this tool.
	8	7.800