DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and SSY1

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_010444.1	Gene:	SSY1 / 851738	SGDID:	S000002567	Length:	852	Species:	Saccharomyces cerevisiae

Alignment Length:	600	Identity:	112/600 - (18%)
Similarity:	208/600 - (34%)	Gaps:	173/600 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TRKKPLEDSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGP-AVVVSFLIAAIASI 86
            |||..::        :.|....:..|.||:...||:::.:|: :...||| ..::.|.:.....:
Yeast   272 TRKYHIQ--------RKLKVRHIQMLSIGACFSVGLFLTSGK-AFSIAGPFGTLLGFGLTGSIIL 327

  Fly    87 FAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLDQLCGNP 151
            ...|.:.|....:|.:......:...:.:...|.:||...:...:...:.|.. ||:
Yeast   328 ATMLSFTELSTLIPVSSGFSGLASRFVEDAFGFALGWTYWISCMLALPAQVSS-STF-------- 383

  Fly   152 MSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGL 216
               :|..:..:||.     ..:.|..:|:..:.:|.|         |:..:..:|.:::|  ||:
Yeast   384 ---YLSYYNNVNIS-----KGVTAGFITLFSAFSIVV---------NLLDVSIMGEIVYV--AGI 429

  Fly   217 FKV---------------SSSN----------WSIPKSQVPEGYG---------DGG-FMPYGVS 246
            .||               ...|          |...||.....||         |.| ....|:|
Yeast   430 SKVIIAILMVFTMIILNAGHGNDIHEGVGFRYWDSSKSVRNLTYGLYRPTFDLADAGEGSKKGIS 494

  Fly   247 G----IIKGAAVCF---YGFIGFDCIATAGEEAKNPKKSIPFAV-----IVSLAMIFLAY-FGVS 298
            |    .:..|:|..   :.|.|.:....|..||.||:|:||.|.     ||.::.:||.: .|::
Yeast   495 GPKGRFLATASVMLISTFAFSGVEMTFLASGEAINPRKTIPSATKRTFSIVLISYVFLIFSVGIN 559

  Fly   299 TVL--TMMLPYFEQDEKAPLPHVFRING--WHV-------AEY-VVSIGA-----------MFGL 340
            ...  ..:|.||....:.....:.:..|  |.:       .:| .:|:|.           .|||
Yeast   560 IYSGDPRLLSYFPGISEKRYEAIIKGTGMDWRLRTNCRGGIDYRQISVGTGYSSPWVVALQNFGL 624

  Fly   341 C---------------SSMMGAMFPLPRIVFAMS---NDGLLFKFLGDISEKYKTPFKGTMITGM 387
            |               ::.:.::|...|.::|||   ....:|    :|..|...|:...:.:.:
Yeast   625 CTFASAFNAILIFFTATAGISSLFSCSRTLYAMSVQRKAPPVF----EICSKRGVPYVSVIFSSL 685

  Fly   388 LTGIL------AAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQ 446
            .:.|.      .|:.|...|.|:.|..|.:.:..:....|...|.:..|::
Yeast   686 FSVIAYIAVDQTAIENFDVLANVSSASTSIIWMGLNLSFLRFYYALKQRKD-------------- 736

  Fly   447 DRPCALWRRIFNLNGQTVPTKQTSR--IVTYSVTLFSLWC--MVFSQILTKFEEDLANVTSFDGI 507
                     |.:.|..:.|.|...:  :..|.:...||:.  |.:...:..|....|..:::.|:
Yeast   737 ---------IISRNDSSYPYKSPFQPYLAIYGLVGCSLFVIFMGYPNFIHHFWSTKAFFSAYGGL 792

  Fly   508 KL---------VLGT 513
            ..         ||||
Yeast   793 MFFFISYTAYKVLGT 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	111/599 (19%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
SSY1	NP_010444.1	2A0310	278..819	CDD:273334	108/593 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.760