Protein Alignment CG5535 and SLC7A3

DIOPT Version :10

• Sequence 1: NP_649019.2
• Gene: CG5535 / 39990
• FlyBaseID: FBgn0036764
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_116192.4
• Gene: SLC7A3 / 84889
• HGNCID: 11061
• Length: 619
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 274/631 - (43%)
• Similarity: 395/631 - (62%)
• Gaps: 49/631 - (7%)

  Fly    10 MPSWSVTNAF-RVLTRKKPLEDS-NESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGP 72
            || |.....| :.|.|::.||.. .|::||:.||..||.|||:|||||.|||||||||:|..|||
Human     1 MP-WQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGP 64

  Fly    73 AVVVSFLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVV 137
            ::|:.||:||::|:.|||||||||||||::||||:|||||:||..||..||||||.|.||:|||.
Human    65 SIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVA 129

  Fly   138 KGLSTYLDQLCGNPMSSFLGTHMPLNI-EGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFT 201
            :..|:..|.|.||.:|..|...:.|:: ..:..|||.||..:.:|.:..:|:||.||..|..|||
Human   130 RAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFT 194

  Fly   202 MLNLGVVLFVIIAGLFKVSSSNWSIPK-------SQVPEGY-----GDGGFMPYGVSGIIKGAAV 254
            .:||.|:.||:|:|..|....||.:.:       :::.:.|     |.|||:|:|..||::|||.
Human   195 GVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAAT 259

  Fly   255 CFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHV 319
            |||.|:|||||||.||||:||::|||..:::||::.|||||.||:.||:|:||::...::|||..
Human   260 CFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEA 324

  Fly   320 FRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMI 384
            |...||..|.|||::|::..|.:|::|:|||:||:::||:.|||||:.|..|....:||...|::
Human   325 FLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVV 389

  Fly   385 TGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQD-- 447
            :|::...:|.:|.|:.||::||||||||||:|:.|||:|||:.|...::     |....|:::
Human   390 SGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKT-----GEEVELQEEAI 449

  Fly   448 ----RPCALWRRIFNLNGQTVPTKQTSRIV----TYSVTLFSLWCMVFSQILTKFEEDLANVTSF 504
                ....||...|.||  ::||..:.:||    :....|.:..|:|.:|         .:|...
Human   450 TTESEKLTLWGLFFPLN--SIPTPLSGQIVYVCSSLLAVLLTALCLVLAQ---------WSVPLL 503

  Fly   505 DGIKLVLGTIPLAVLLL-----VISRQPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDILTWI 564
            .|..|....:.|.:||:     ||.|||.|...|.||||.:|.||.:||.:|||||:::...||.
Human   504 SGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWA 568

  Fly   565 RFSIWIAIGLAIFLAYGIRHS--RLRQREQRNNSIAMMRDCSNSAL 608
            ||.:|:.||.||:..|||:||  .::..:....|.|...|.....|
Human   569 RFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSRKSRAKTVDLDPGTL 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	264/593 (45%)
SLC7A3	NP_116192.4	2A0303	9..591	CDD:273330	267/597 (45%)