Protein Alignment CG5535 and SLC7A4

DIOPT Version :9

• Sequence 1: NP_649019.2
• Gene: CG5535 / 39990
• FlyBaseID: FBgn0036764
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_004164.2
• Gene: SLC7A4 / 6545
• HGNCID: 11062
• Length: 635
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 237/615 - (38%)
• Similarity: 362/615 - (58%)
• Gaps: 54/615 - (8%)

  Fly     9 GMPS-WSVTNAFRVLTRKKPLEDSN-ESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAG 71
            |:|: .|:....:.|.|.||||||. |:.|.:.||..|||.||:|..:|.|:|||.|.|:|:.||
Human     4 GLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAG 68

  Fly    72 PAVVVSFLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASV 136
            |||::||.:||:||:.|.|||||||||||:.||||:::||::||..|||||||::|||.||.|:|
Human    69 PAVLLSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAV 133

  Fly   137 VKGLSTYLDQLCGNPMSSFLGTH-----MPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRV 196
            .:..|.|||.:..:.:.:|..||     :||    :|.|||..|..:.:|.|..::.||:.|:.:
Human   134 ARAWSGYLDSMFSHSIRNFTETHVGSWQVPL----LGHYPDFLAAGIILLASAFVSCGARVSSWL 194

  Fly   197 NNVFTMLNLGVVLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIG 261
            |:.|:.::|.|:||::|.|.......|||.         .:|||.|:|.||::.|.|.|||.|:|
Human   195 NHTFSAISLLVILFIVILGFILAQPHNWSA---------DEGGFAPFGFSGVMAGTASCFYAFVG 250

  Fly   262 FDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWH 326
            ||.||.:.|||:||::|:|.|:.:|||:...||..||||||:|:|:...|..:.|...|...|:.
Human   251 FDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYR 315

  Fly   327 VAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGI 391
            .|.::|:.|::..:.:.::..:|.|||||:||:.|||.|:....:..:.:.|..||:..|:||..
Human   316 WAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAF 380

  Fly   392 LAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCALWRRI 456
            ||.:.:|..||..:|:||||||:.||:.:::||::......|        .|.....|....:..
Human   381 LALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQKSSPPSS--------PGPASPGPLTKQQSS 437

  Fly   457 FNLNGQTVPTKQTS------------------------RIVTYSVTLFSLWCMVFSQILTKFEED 497
            |:.:.|.|.|...|                        .:||:::.:.....:....:|. |...
Human   438 FSDHLQLVGTVHASVPEPGELKPALRPYLGFLDGYSPGAVVTWALGVMLASAITIGCVLV-FGNS 501

  Fly   498 LANVTSFDGIKLVLGTIPLAVL-LLVISRQPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDIL 561
            ..::..:..|.|:|.|..:.:| |||:........:..|::|:||.:|.:||::||.||:||..|
Human   502 TLHLPHWGYILLLLLTSVMFLLSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYL 566

  Fly   562 TWIRFSIWIAIGLAIFLAYGIRHSRLRQRE 591
            ||:|||||:.:|||::..||||||:..|||
Human   567 TWVRFSIWLLMGLAVYFGYGIRHSKENQRE 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	229/595 (38%)
		AA_permease_C	535..585	CDD:290617	28/49 (57%)
SLC7A4	NP_004164.2	2A0303	26..592	CDD:273330	225/587 (38%)
		AA_permease_C	540..590	CDD:290617	28/49 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157272
Domainoid	1	1.000	76	1.000	Domainoid score	I8973
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.680