Protein Alignment CG5535 and SLC7A2

DIOPT Version :10

• Sequence 1: NP_649019.2
• Gene: CG5535 / 39990
• FlyBaseID: FBgn0036764
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001158243.1
• Gene: SLC7A2 / 6542
• HGNCID: 11060
• Length: 698
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 274/605 - (45%)
• Similarity: 391/605 - (64%)
• Gaps: 29/605 - (4%)

  Fly    20 RVLTRKK--PLEDSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLIAA 82
            |.|.|:|  .|:...::||.:.||..||.|||:|||||.|||||||||:|..:||::||||||||
Human    52 RCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAA 116

  Fly    83 IASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLDQL 147
            :||:.||||||||||||||.||||:|:|||:||..||:.||||||.|.||::||.:..|...|:|
Human   117 LASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDEL 181

  Fly   148 CGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVI 212
            ....:..||.|:..:|..|:..|||.||..:.:|.:..::.|.|||..||.|||.:|:.|:|||:
Human   182 LSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVM 246

  Fly   213 IAGLFKVSSSNWSI---------------PKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGF 262
            :||..|.:.:||.|               |.......||.|||||||.:|.:.|||.|||.|:||
Human   247 VAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGF 311

  Fly   263 DCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHV 327
            |||||.|||.:||:|:||..::.||.:.|:||||||..||:|:||:..|||:|||..|...||..
Human   312 DCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGP 376

  Fly   328 AEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGIL 392
            |:|||:.|::..|.:|::|::||:||:::||:.||||||.|..|:.|.|||...|:.:|.:..::
Human   377 AKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALM 441

  Fly   393 AAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYE----VDDRR----ESRIVANGRATGLEQDRP 449
            |.:|:|..||:|||||||:|||:||:|||:|||:    .|..:    :..:.::.|.|...:.:.
Human   442 AFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQV 506

  Fly   450 CALWRRIFNLN----GQTVPTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDLANVTSFDGIKLV 510
            ..|.|:.|::.    ...:||:|::.:|::.|...:...:..|.:.|.....:..:.::....|.
Human   507 TMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLA 571

  Fly   511 LGTIPLAVLLLVISRQPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDILTWIRFSIWIAIGLA 575
            |..:....::|.|.|||.:..|::|.||.:|:||..|||:|||||::|...||:|||||:|||..
Human   572 LFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFL 636

  Fly   576 IFLAYGIRHSRLRQREQRNN 595
            |:.:||||||........||
Human   637 IYFSYGIRHSLEGHLRDENN 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	270/593 (46%)
SLC7A2	NP_001158243.1	2A0303	45..648	CDD:273330	272/595 (46%)