Protein Alignment CG5535 and SLC7A2

DIOPT Version :9

• Sequence 1: NP_649019.2
• Gene: CG5535 / 39990
• FlyBaseID: FBgn0036764
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001158243.1
• Gene: SLC7A2 / 6542
• HGNCID: 11060
• Length: 698
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 274/605 - (45%)
• Similarity: 391/605 - (64%)
• Gaps: 29/605 - (4%)

  Fly    20 RVLTRKK--PLEDSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLIAA 82
            |.|.|:|  .|:...::||.:.||..||.|||:|||||.|||||||||:|..:||::||||||||
Human    52 RCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAA 116

  Fly    83 IASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLDQL 147
            :||:.||||||||||||||.||||:|:|||:||..||:.||||||.|.||::||.:..|...|:|
Human   117 LASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDEL 181

  Fly   148 CGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVI 212
            ....:..||.|:..:|..|:..|||.||..:.:|.:..::.|.|||..||.|||.:|:.|:|||:
Human   182 LSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVM 246

  Fly   213 IAGLFKVSSSNWSI---------------PKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGF 262
            :||..|.:.:||.|               |.......||.|||||||.:|.:.|||.|||.|:||
Human   247 VAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGF 311

  Fly   263 DCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHV 327
            |||||.|||.:||:|:||..::.||.:.|:||||||..||:|:||:..|||:|||..|...||..
Human   312 DCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGP 376

  Fly   328 AEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGIL 392
            |:|||:.|::..|.:|::|::||:||:::||:.||||||.|..|:.|.|||...|:.:|.:..::
Human   377 AKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALM 441

  Fly   393 AAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYE----VDDRR----ESRIVANGRATGLEQDRP 449
            |.:|:|..||:|||||||:|||:||:|||:|||:    .|..:    :..:.::.|.|...:.:.
Human   442 AFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQV 506

  Fly   450 CALWRRIFNLN----GQTVPTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDLANVTSFDGIKLV 510
            ..|.|:.|::.    ...:||:|::.:|::.|...:...:..|.:.|.....:..:.::....|.
Human   507 TMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLA 571

  Fly   511 LGTIPLAVLLLVISRQPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDILTWIRFSIWIAIGLA 575
            |..:....::|.|.|||.:..|::|.||.:|:||..|||:|||||::|...||:|||||:|||..
Human   572 LFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFL 636

  Fly   576 IFLAYGIRHSRLRQREQRNN 595
            |:.:||||||........||
Human   637 IYFSYGIRHSLEGHLRDENN 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	270/593 (46%)
		AA_permease_C	535..585	CDD:290617	30/49 (61%)
SLC7A2	NP_001158243.1	2A0303	45..648	CDD:273330	272/595 (46%)
		AA_permease_C	596..646	CDD:290617	30/49 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157251
Domainoid	1	1.000	463	1.000	Domainoid score	I475
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1172
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8495
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840