DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5535 and SLC7A1

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_016876202.1	Gene:	SLC7A1 / 6541	HGNCID:	11057	Length:	643	Species:	Homo sapiens

Alignment Length:	565	Identity:	247/565 - (43%)
Similarity:	362/565 - (64%)	Gaps:	50/565 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NAFRVLTRKKPLEDS-NESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLI 80
            |..:.:.|:|.::.| .|::|::.|:.|||.|||:|||||.|||||||.|:::.||||:|:||||
Human     8 NIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLI 72

  Fly    81 AAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLD 145
            ||:||:.|||||.||||||||.||||:|||||:||..||:.||||||.|.||::||.:..|...|
Human    73 AALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFD 137

  Fly   146 QLCGNPMSSFLGTHMPLNIEG-MGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVL 209
            :|.|.|:..|..|||.||..| :...||:||.::.::.:..:.:|.|||..||.:||.:|:.|:.
Human   138 ELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLG 202

  Fly   210 FVIIAGLFKVSSSNWSIPK-------------SQVPEGY-GDGGFMPYGVSGIIKGAAVCFYGFI 260
            |::::|..|.|..||.:.:             :...||. |.|||||:|.||::.|||.|||.|:
Human   203 FIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFV 267

  Fly   261 GFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGW 325
            |||||||.|||.|||:|:||..::.||.:.|:||||||..||:|:|||..|..:|||..|:..||
Human   268 GFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGW 332

  Fly   326 HVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTG 390
            ..|:|.|::|::..|.:|::|:|||:||:::||:.||||||||.:::::.|||...|:.:|.:..
Human   333 EGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAA 397

  Fly   391 ILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRY----------------EVDDRRESRIVA-N 438
            ::|.:|:|..||::||||||||||:||:|||:|||                |:|...::.:.: |
Human   398 VMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTN 462

  Fly   439 GRATGLEQDRPCALWRRIFNLNGQTV-------PTKQTSRIVTYSVTLFSLWCMVFSQILTKFEE 496
            ....|...:      ..:|:|  :|:       |:|.:..||..|.:|.::..:.|. |:|....
Human   463 DSQLGFLPE------AEMFSL--KTILSPKNMEPSKISGLIVNISTSLIAVLIITFC-IVTVLGR 518

  Fly   497 DLANVTSFDGIKLVLGTIPL-AVLLLVISRQPTSGVKLSFKVPLV 540
            :.....:...:.|:.|:..| ||:..||.|||.|..|||||..|:
Human   519 EALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKTVLL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	246/562 (44%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	3/6 (50%)
SLC7A1	XP_016876202.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157301
Domainoid	1	1.000	463	1.000	Domainoid score	I475
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20658
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1172
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8495
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840