DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5535 and SLC7A14

DIOPT Version :10

Sequence 1:NP_649019.2 Gene:CG5535 / 39990 FlyBaseID:FBgn0036764 Length:630 Species:Drosophila melanogaster
Sequence 2:NP_066000.2 Gene:SLC7A14 / 57709 HGNCID:29326 Length:771 Species:Homo sapiens


Alignment Length:693 Identity:265/693 - (38%)
Similarity:399/693 - (57%) Gaps:128/693 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 AEYYGMPSWSVTNAFRVLTRKKPLEDSNE---------SKLAKVLSAFDLTALGIGSTLGVGVYV 60
            |.:|.|.|       |:| |.||:|...|         :|||:||:..||.:||:||.:|.|:||
Human    17 AAWYAMHS-------RIL-RTKPVESMLEGTGTTTAHGTKLAQVLTTVDLISLGVGSCVGTGMYV 73

  Fly    61 LAGEVSKQYAGPAVVVSFLIAAIASIFAGLCYAEFGARVPK-AGSAYIYSYVTIGEFIAFLIGWN 124
            ::|.|:|:.|||.|:|||:|||:|||.:|:||||||.|||| .||||.|||||:|||:||.||||
Human    74 VSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWN 138

  Fly   125 LILEYAIGSASVVKGLSTYLDQLCGNPMSSFL----GTHMPLNIEGMG--AYPDLFAFVVTILFS 183
            |||||.||:|:....||:..|.|..:.:|.::    ||   ||..|.|  :||||.|.::.::.:
Human   139 LILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGT---LNGLGKGEESYPDLLALLIAVIVT 200

  Fly   184 LAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGI 248
            :.:|:|.|.|...|||..:|||.|.:|::|||||.::...|:           :|.|:|:|.||:
Human   201 IIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGLFFINGKYWA-----------EGQFLPHGWSGV 254

  Fly   249 IKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEK 313
            ::|||.|||.|||||.|||.|||||||..|||:|:..||.:...||..||.:||:|:||:..|.:
Human   255 LQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTE 319

  Fly   314 APLPHVFRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTP 378
            :||..:|..:|::.|::||:||::.||..|::|::||:||:::||:.|||||:||..:|...:||
Human   320 SPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETP 384

  Fly   379 FKGTMITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDD-------------- 429
            ....:::|.|..:||.:.:|..|:.||||||||||::|:.|||:|||:.:.              
Human   385 VVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHT 449

  Fly   430 RRESRIVAN--------------------------------------GRA--------------- 441
            :::..|:|:                                      |::               
Human   450 KKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTV 514

  Fly   442 ---TGLEQDRPCALW----RRIFNLNGQTV------------PTKQTSRIVTYSVTLFSLWCMVF 487
               ||:|.|....::    :::...:..|:            ||..|...||..|.|..:...:|
Human   515 DMTTGIEADESENIYLIKLKKLIGPHYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIF 579

  Fly   488 SQILTKFEEDLANVTSFDGIKL-VLGTIPLAVLLLVISRQPTSGVKLSFKVPLVPWLPGISILIN 551
            ...:. |..|..:..|:..|.| ||..:.::.|:.||.:||.:..||.:..|.:|::|..::|:|
Human   580 CSFII-FGSDYISEQSWWAILLVVLMVLLISTLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVN 643

  Fly   552 IYLMIKLDILTWIRFSIWIAIGLAIFLAYGIRHSRLR--QREQ 592
            ||||:||..:|||||::|..:||.|:..|||.:|.|.  .||:
Human   644 IYLMLKLSTITWIRFAVWCFVGLLIYFGYGIWNSTLEISAREE 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5535NP_649019.2 2A0303 20..585 CDD:273330 257/667 (39%)
SLC7A14NP_066000.2 2A0303 48..677 CDD:273330 250/643 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 736..771
Blue background indicates that the domain is not in the aligned region.

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