DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and si:dkeyp-120h9.1

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001093492.1	Gene:	si:dkeyp-120h9.1 / 566469	ZFINID:	ZDB-GENE-070705-534	Length:	487	Species:	Danio rerio

Alignment Length:	512	Identity:	115/512 - (22%)
Similarity:	210/512 - (41%)	Gaps:	85/512 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SNESKLAKVLSAFDLTALGIGSTLGVGVYVL-AGEVSKQYAGPAVVVSFLIAAIASIFAGLCYAE 94
            ::..:|.:.:|......|.:|:.:|.|::|. .|.:.|..:....:|.:.|..|.|:|..|||||
Zfish     7 TSSMRLKQEISLLHGVCLIVGNMIGSGIFVSPIGVLEKTGSYGLSLVVWAIGGIFSVFGALCYAE 71

  Fly    95 FGARVPKAGSAYIYSYVTIGEFIAFLIGWN--LILEYAIGSASVVKGLSTYLDQLCGNPMSSFLG 157
            .|..:.|:|::|.|...|.|.|:||:..|.  :|:|.|. .|.:....:.||       :..|..
Zfish    72 LGTTIRKSGASYAYILETFGGFLAFIRLWTSLMIVEPAC-QAVIALTFANYL-------VKPFFP 128

  Fly   158 THMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFKVSSS 222
            | .|...:.:.....|...::||:..:.:..||    .:..:.|:..:..::.:||||:..::..
Zfish   129 T-CPAPYDAVRLIAALIIGLLTIVNCMKVKWGA----ILQVISTVAKVLALIVIIIAGMVVLAQG 188

  Fly   223 NWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSL 287
            ..:..:........|.|.|...:...:       |.:.|:|.:....||.|||::::|.::.:|:
Zfish   189 ETNNFRDSFENSKLDPGNMSLALYAAL-------YSYSGWDTLNFITEEIKNPERNLPLSIAISM 246

  Fly   288 AMIFL-------AYFGVSTVLTMMLPYFEQDEKAPL---PHVFRINGWHVAEYVVSIGAMFGLCS 342
            .::.:       ||:.|..:.|::     |.|...:   .:|.....| :....|:|....||.|
Zfish   247 PIVTIIYILTNVAYYAVLDMNTLL-----QSEAVAVTFADYVLGYASW-LIPLSVAISCYGGLNS 305

  Fly   343 SMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLVNMMSI 407
            |::.|    .|:.|..|.:|.|...|..|..|..||....:..|.::.|...|.::.||:|..|.
Zfish   306 SIIAA----SRLFFVGSREGHLPNVLCMIHVKRYTPIPALLFNGGMSLIYLCVRDVFQLINYFSF 366

  Fly   408 GTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCALWRRIFNLNGQTVPTKQTSRI 472
            ...|...:.....:.||::..|                ..||..|  .:|      .|
Zfish   367 NYWLFIGLSIGSQIYLRFKAPD----------------MPRPIKL--SLF------FP------- 400

  Fly   473 VTYSVTLFSLWCMVFSQILTKFEEDLANVTSFDGIKLVLGTIPLAVLLLVISRQPTS 529
            :.|.:      |.||..::..:.:   .:.|..||.:.|...|  |..:.:...|:|
Zfish   401 IVYCL------CSVFLVVVPLYSD---TINSLVGIAVALSGAP--VYYICVHLPPSS 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	115/512 (22%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
si:dkeyp-120h9.1	NP_001093492.1	2A0308	12..466	CDD:273332	115/507 (23%)
si:dkeyp-120h9.1	NP_001093492.1	SLC5-6-like_sbd	16..>263	CDD:294310	63/266 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850