DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and slc7a1a

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_021327949.1	Gene:	slc7a1a / 559627	ZFINID:	ZDB-GENE-091116-69	Length:	651	Species:	Danio rerio

Alignment Length:	601	Identity:	272/601 - (45%)
Similarity:	389/601 - (64%)	Gaps:	66/601 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLIAAIASIFAGLCYAE 94
            :|.||:|::.|:.|||.|||:|||||.|||||||.|:::.||||:|:||||||:||:.|||||||
Zfish    22 NSEESRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVLSFLIAALASVLAGLCYAE 86

  Fly    95 FGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLDQLCGNPMSSFLGTH 159
            |||||||.||||:|||||:||..||:.||||||.|.||::||.:..|...|:|.|..:..|...:
Zfish    87 FGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYVIGTSSVARAWSATFDELIGKHIEHFCRQY 151

  Fly   160 MPLNIEG-MGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFKVSSSN 223
            |.:|..| :..|||:|:..:.:..:..:|.|.|||..||.|||.:|:.|:||::::||.|.:..|
Zfish   152 MSMNAPGVLAEYPDMFSVFIILTLTGLLAFGVKESAMVNKVFTCINILVLLFMVVSGLVKGTLKN 216

  Fly   224 WSIPKSQV----------------PEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEA 272
            |.:...::                .|..|.|||||:|.:|::.|||.|||.|:|||||||.|||.
Zfish   217 WHLDPDEILNATNSTLNATQPLPSEEMLGQGGFMPFGFTGVLSGAATCFYAFVGFDCIATTGEEV 281

  Fly   273 KNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSIGAM 337
            |||:::||..::.||.:.|:||||||..||||:||:..|:.:|||..|:..||..|.|.|::|::
Zfish   282 KNPQRAIPIGIVSSLLICFVAYFGVSAALTMMMPYYMLDKNSPLPVAFKYVGWEGATYAVAVGSL 346

  Fly   338 FGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLV 402
            ..|.:|::|||||:||:::||::|||||||:..|||:.|||.|.|:::|.|..|:|.:|:|..||
Zfish   347 CALSTSLLGAMFPMPRVLWAMADDGLLFKFMAGISERTKTPIKATIMSGFLAAIMAFLFDLKDLV 411

  Fly   403 NMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVAN----------------GRATGLEQDRPCA 451
            ::|||||||||::||:|||:|||:.:...::..:||                |...|:|:
Zfish   412 DLMSIGTLLAYTLVAACVLVLRYQPEQFSQTYHIANTHEDMEMSETISTPSMGILPGVEE----- 471

  Fly   452 LWRRIF------------NLNGQTVPTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDLANVTSF 504
              |..|            ||:|.||      .|.|   :|..|..:.||.:..:     ..:.|:
Zfish   472 --RFSFKNLLFPDIIEPSNLSGFTV------NICT---SLLGLLILSFSLLAVR-----GGIASW 520

  Fly   505 DGIKLVLGTIPLAVLLLVISRQPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDILTWIRFSIW 569
            :.|.|.:......::..:|.|||.|..|||||||.:|::|.:|:.:|:|||::||..|||||:||
Zfish   521 NIITLAVLFGLCVIVTFIIWRQPESKTKLSFKVPCLPFIPVVSMFVNVYLMMQLDRGTWIRFAIW 585

  Fly   570 IAIGLAIFLAYGIRHS 585
            ::|||.|:..|||.||
Zfish   586 MSIGLVIYFGYGIWHS 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	270/599 (45%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	27/49 (55%)
slc7a1a	XP_021327949.1	2A0303	4..603	CDD:273330	272/601 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593066
Domainoid	1	1.000	463	1.000	Domainoid score	I454
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20658
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1071
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm6524
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940