DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and slc7a10b

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_687825.2	Gene:	slc7a10b / 559395	ZFINID:	ZDB-GENE-121105-2	Length:	517	Species:	Danio rerio

Alignment Length:	444	Identity:	105/444 - (23%)
Similarity:	190/444 - (42%)	Gaps:	87/444 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RKKPLEDSNESK---------LAKVLSAFDLTALGIGSTLGVGVYVL-------AGEVSKQYAGP 72
            |:..::||...:         |.|.:.......:.||:.:|.|:::.       :|.|     |.
Zfish    12 RRSIMKDSELKRDSGIPERVTLKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSV-----GL 71

  Fly    73 AVVVSFLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVT--IGEFIAFLIGWNLIL-EYAIGSA 134
            |:||..|...:|:: ..|||||.|..:||:|..  |||||  .|..:.||:.|:.:| .|....|
Zfish    72 ALVVWMLGGGVAAL-GSLCYAELGVTIPKSGGD--YSYVTEIFGGLVGFLLLWSAVLIMYPTTLA 133

  Fly   135 SVVKGLSTYLDQ----LCGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTR 195
            .:....|:|:.|    .|..|   ::.|.|      :.|...||...|. .:|:.:|      ||
Zfish   134 VIALTFSSYVLQPVFPHCVPP---YIATRM------LSAICILFLTWVN-CYSVRLA------TR 182

  Fly   196 VNNVFTMLNLGVVLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCF---- 256
            :.:.||:..|..:..:|..||.::...|:   :|..|:     ....:..:..|...|:.|
Zfish   183 IQDAFTVGKLLALGLIITVGLVQICGGNY---ESLTPQ-----TAFTFNKAPSIGQIALAFLHAS 239

  Fly   257 YGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFR 321
            :.|.|::.:....||..:|::::|.|:.:|:.::...|     .|| .:.||.......|
Zfish   240 FAFSGWNFLNYVTEEVVDPRRNLPRAIYISIPLVTCVY-----TLT-NIAYFSSMSPEEL----- 293

  Fly   322 INGWHVAEYVVSIG-AMFGLCSSMM-------------GAMFPLPRIVFAMSNDGLLFKFLGDIS 372
            ::...||   |:.| .:.|:.|::|             |.:|...|:.|:.:.:|.|...|..|.
Zfish   294 LSSNAVA---VTFGEKLLGMFSTLMPISVALSTFGGINGYLFTSSRLCFSGAREGHLPSLLAMIH 355

  Fly   373 EKYKTPFKGTMITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYE 426
            .|:.||....::....|.::..:.....|:|.:|....|:|.:..:.:|..|::
Zfish   356 FKHCTPIPALLVCCTATIVILCIGETHNLINYVSFINYLSYGVTIAGLLYYRWK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	105/444 (24%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
slc7a10b	XP_687825.2	2A0308	29..494	CDD:273332	102/427 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940