DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and slif

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	307/586 - (52%)
Similarity:	420/586 - (71%)	Gaps:	18/586 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VTNAFRVLTRKKPLEDSN--ESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVS 77
            :||.::.|||:| .||.|  ||:||:||:.|||||||:|||||:|||||||:|:...|||||.:|
  Fly     1 MTNLWKALTRRK-TEDVNEGESQLARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPAVTIS 64

  Fly    78 FLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLST 142
            ||||||||.|||:|||||.||||||||||:|||||||||:||.|||||||||.||:|||.:|||.
  Fly    65 FLIAAIASAFAGICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSG 129

  Fly   143 YLDQLCGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGV 207
            |.|.|..|.||..|...|.::::.:|.|||..:|.:.:|.:..:|.|||||:.:||:||.:||..
  Fly   130 YFDSLINNNMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNLVT 194

  Fly   208 VLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEA 272
            :..|::||....:..||.|||..||||:|.|||||:|::|::.|||.|||||:|||||||.||||
  Fly   195 IAIVLVAGAMNANVDNWRIPKKDVPEGFGTGGFMPFGIAGVMAGAAKCFYGFVGFDCIATTGEEA 259

  Fly   273 KNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSIGAM 337
            .|||::||.:::|||.:|||:||||||||||||||::||:.||.||.|....|:..:::|:|||:
  Fly   260 INPKRNIPLSIVVSLIIIFLSYFGVSTVLTMMLPYYKQDKDAPFPHAFDSVEWYTIKWIVTIGAV 324

  Fly   338 FGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLV 402
            |.||:|::|||||||||::||..||:|||.|..::...|||...|:::|:...|:|.:|||.|||
  Fly   325 FALCTSLLGAMFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFASIMAMLFNLDQLV 389

  Fly   403 NMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCALWRRIFNLNGQTVPTK 467
            :||||||||||::||.|||:|||:.::           .|.|...:...::|:.||.|....|..
  Fly   390 DMMSIGTLLAYTIVAICVLVLRYQDEE-----------MTKLVSVKAPNVFRQFFNGNSFREPNS 443

  Fly   468 QTSRIVTYSVTLFSLWCMVFSQILTKFEEDLANVTSFDGIKLVLGTIPLAVLLLVISRQPTSGVK 532
            .||.|....:.:|:::|:|:..:...|  ||.:......:.|| |.: |.::.:||..||.|.::
  Fly   444 MTSSITKVGIVVFAIFCLVWCSLQKVF--DLDSTGGIVALSLV-GAV-LILICVVIGMQPVSTIE 504

  Fly   533 LSFKVPLVPWLPGISILINIYLMIKLDILTWIRFSIWIAIGLAIFLAYGIRHSRLRQREQRNNSI 597
            |:|||||||::|.:|:..|:|||.:||:.|||||.|||.||..|:..||:|:|....|.:.:..:
  Fly   505 LTFKVPLVPFVPCLSVFANLYLMFQLDLNTWIRFLIWIVIGYVIYFCYGMRNSTQISRSRSHAEV 569

  Fly   598 A 598
            |
  Fly   570 A 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	302/566 (53%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	29/49 (59%)
slif	NP_649428.1	2A0303	8..557	CDD:273330	302/564 (54%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617	29/49 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469328
Domainoid	1	1.000	307	1.000	Domainoid score	I322
eggNOG	1	0.900	-	-		E2759_KOG1286
Homologene	1	1.000	-	-		H20658
Inparanoid	1	1.050	352	1.000	Inparanoid score	I609
Isobase	1	0.950	-	0	Normalized mean entropy	S2925
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40603at33392
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm6524
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	P	PTHR43243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2006
SonicParanoid	1	1.000	-	-		X81
	14	13.780