DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5535 and Slc7a11

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_038958186.1	Gene:	Slc7a11 / 310392	RGDID:	1309275	Length:	505	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	115/542 - (21%)
Similarity:	212/542 - (39%)	Gaps:	103/542 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLIA-AIASIFAGLCYAEFGARV 99
            |.|.::.....::.||:.:|.|:::....:.:......:.:.|..| .:.|:|..|.|||.|..:
  Rat    40 LKKKITLLRGVSIIIGTVIGSGIFISPKGILQNTGSVGMSLVFWSACGVLSLFGALSYAELGTSI 104

  Fly   100 PKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVK-GLSTYLDQLCGNPMSSFLGTHMP-L 162
            .|:|..|.|.....|..:||:..|..:|....|:.:|:. ....|:.:    |.  |:...:| |
  Rat   105 KKSGGHYTYILEVFGPLLAFVRVWVELLVIRPGATAVISLAFGRYILE----PF--FIQCEIPEL 163

  Fly   163 NIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGL----------F 217
            .|:.:.|   :...||.:|.|.:::    .|.|:....|...|..:|.:|:.|:          |
  Rat   164 AIKLVTA---VGITVVMVLNSTSVS----WSARIQIFLTFCKLTAILIIIVPGVIQLIKGQTHHF 221

  Fly   218 KVSSSNWSIPKSQVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFA 282
            |.:.|........:|..:      .||:           |.:.|:..:....||..||:|:||.|
  Rat   222 KDAFSGRDTNLMGLPLAF------YYGM-----------YAYAGWFYLNFITEEVDNPEKTIPLA 269

  Fly   283 VIVSLAMIFLAYF--GVSTVLTMMLPYFEQDEKAPLPHVFRING-WHVAEYVVSIGAMFGLCSSM 344
            :.:|:|:|.:.|.  .|:...|:......|.....:....|:.| :.:|..:....:.||   ||
  Rat   270 ICISMAIITVGYVLTNVAYFTTISAEELLQSSAVAVTFSERLLGKFSLAVPIFVALSCFG---SM 331

  Fly   345 MGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLVNMMSIGT 409
            .|.:|.:.|:.:..|.:|.|.:.|..|.....||....::...||.|:....:|..|:|.:|...
  Rat   332 NGGVFAVSRLFYVASREGHLPEILSMIHVHKHTPLPAVIVLHPLTMIMLFSGDLYSLLNFLSFAR 396

  Fly   410 LLAYSMVASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCALWRRIFNLNGQTVPTKQTSRIVT 474
            .|...:..:.::.|||:..|                ..||                    .::..
  Rat   397 WLFMGLAVAGLIYLRYKRPD----------------MHRP--------------------FKVPL 425

  Fly   475 YSVTLFSLWCMVFSQILTKFEEDLANVTSFDGIKLVLGTIPLAVLLLVISRQPTSGVKLSFKVPL 539
            :...|||..|: |..:|:.:.:..:...   |..:.|..:|...|.:|..::|
  Rat   426 FIPALFSFTCL-FMVVLSLYSDPFSTGV---GFLITLTGVPAYYLFIVWDKKP------------ 474

  Fly   540 VPWLPGISILINIYLMIKLDIL 561
             .|...:|: .|::..:|...|
  Rat   475 -KWFRRLSV-NNLHFSLKSTFL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	115/542 (21%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	5/27 (19%)
Slc7a11	XP_038958186.1	2A0308	1..482	CDD:273332	111/527 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351205
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850