DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and Slc7a3

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_058913.1	Gene:	Slc7a3 / 29485	RGDID:	68342	Length:	619	Species:	Rattus norvegicus

Alignment Length:	610	Identity:	273/610 - (44%)
Similarity:	388/610 - (63%)	Gaps:	60/610 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WSVTNAF-RVLTRKKPLE-DSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVV 75
            |.....| :.|.|::.|| ...|::||:.||..||.|||:|||||.|||||||||:|:.|||::|
  Rat     3 WQALRRFGQKLVRRRLLELGMGETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKEKAGPSIV 67

  Fly    76 VSFLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGL 140
            :.||:||::|:.|||||||||||||.:||||:|||||:||..||..||||||.|.||:|||.:..
  Rat    68 ICFLVAALSSVLAGLCYAEFGARVPGSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAW 132

  Fly   141 STYLDQLCGNPMSSFLGTHMPLNI-EGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLN 204
            |:..|.|.||.:|..|...:.||: ..:..|||.||..:.:|.:..:.:||.||..|..|||.:|
  Rat   133 SSAFDNLIGNHISQTLKGTILLNMPHVLAEYPDFFALALVLLLTGLLVLGANESGLVTKVFTGMN 197

  Fly   205 LGVVLFVIIAGLFKVSSSNWSIPKSQVPEGY----------------GDGGFMPYGVSGIIKGAA 253
            |.|:.||||:|..|....||.:.|    |.|                |.|||||:|:.||::|||
  Rat   198 LLVLGFVIISGFIKGELRNWKLTK----EDYCLTMSESNGTCSLDSMGSGGFMPFGLEGILRGAA 258

  Fly   254 VCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPH 318
            .|||.|:|||||||.||||:||::|||..:::||::.||||||||:.||:|:||::...::|||.
  Rat   259 TCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSICFLAYFGVSSALTLMMPYYKLQPESPLPE 323

  Fly   319 VFRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTM 383
            .|...||..|.|:|:||::..|.:|::|:|||:||:::||:.|||||:.|..:.....||...|:
  Rat   324 AFTYVGWEPARYLVAIGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARVHNGTHTPIVATV 388

  Fly   384 ITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDDRRESRIVANG-RATGLEQD 447
            ::|::...:|.:|.|:.||::||||||||||:|:.|||:|||:.|..     :.|| ....|:::
  Rat   389 VSGVIAAFMAFLFELTDLVDLMSIGTLLAYSLVSICVLILRYQPDQE-----MKNGEEEVELQEE 448

  Fly   448 RPC--------ALWRRIFNLNGQTVPTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDLAN---- 500
            |..        ||:.::     .::||..:.|||....:|.::...|...:||.:...|.:
  Rat   449 RTLEAEKLTVQALFCQV-----DSIPTLLSGRIVYVCSSLLAVLLTVLCLVLTWWTTPLHSGDPV 508

  Fly   501 -VTSFDGIKLVLGTIPLAVLLL----VISRQPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDI 560
             ||.   :.|:||      |:|    ||.|||.:...|.||||:||.||.:||.:|:|||:::..
  Rat   509 WVTV---VVLILG------LILGISGVIWRQPQNRTPLHFKVPVVPLLPLVSIFVNVYLMMQMTA 564

  Fly   561 LTWIRFSIWIAIGLAIFLAYGIRHS 585
            .||.||.:|:.||.||:..|||:||
  Rat   565 DTWARFGVWMLIGFAIYFGYGIQHS 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	269/600 (45%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	26/49 (53%)
Slc7a3	NP_058913.1	2A0303	4..591	CDD:273330	272/609 (45%)
Slc7a3	NP_058913.1	AA_permease_C	<551..589	CDD:290617	18/37 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351266
Domainoid	1	1.000	457	1.000	Domainoid score	I470
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1161
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8968
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810