DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5535 and LOC292543

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_006228084.2	Gene:	LOC292543 / 292543	RGDID:	1565097	Length:	681	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	261/621 - (42%)
Similarity:	384/621 - (61%)	Gaps:	50/621 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WSVTNAF-RVLTRKKPL--EDSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAV 74
            |...:.| :.|.|::||  .:.:||.|::.|:..||.:||:|||||.|||||||||:::.|||::
  Rat    52 WQNLHQFGQKLVRRRPLAASEQSESSLSRCLTTLDLVSLGVGSTLGAGVYVLAGEVAREKAGPSI 116

  Fly    75 VVSFLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKG 139
            ::.|||||::|:.:||||||||||||.:||||:|||||:|:.:||:.||||||.|.||:|||.:.
  Rat   117 IICFLIAALSSVMSGLCYAEFGARVPCSGSAYLYSYVTVGQLLAFITGWNLILNYVIGAASVARA 181

  Fly   140 LSTYLDQLCGNPMSSFLGTHMPLNIEG-MGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTML 203
            .|...|.|.||.:|..|.|..|:.:.. :..|||.||..:.|:.:..:|:||:||..|..|||.:
  Rat   182 WSAAFDGLIGNHISQALQTTFPIQVPSFLAKYPDFFALGLVIVLTGILALGARESAMVTRVFTGV 246

  Fly   204 NLGVVLFVIIAGLFKVSSSNWSIPKSQVPEGY----------------GDGGFMPYGVSGIIKGA 252
            ||.|:.||.::|.......||.:.:    :.|                |.|||||:|::||::|.
  Rat   247 NLLVLCFVSLSGFINGKLHNWQLTE----DDYKLALSETNSTDSLGPLGSGGFMPFGLTGILRGT 307

  Fly   253 AVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLP 317
            |.||:.||||||||:.||||:.|::|||..:::||.:.||.|||||:.||:|:||::.:..:|||
  Rat   308 ATCFFAFIGFDCIASTGEEARCPQRSIPLGIVISLFICFLMYFGVSSALTLMMPYYQININSPLP 372

  Fly   318 HVFRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGT 382
            ..|...||..|.|.|::|.:..|.||::|::||:||:|::|:.|||||:.|..:..:..||...|
  Rat   373 QAFIHVGWGPARYAVAVGTLCALSSSLIGSIFPVPRVVYSMAEDGLLFRKLAQVHPRTHTPVLAT 437

  Fly   383 MITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDDRRES--RIVANGRATGLE 445
            ::.|::...:|.:..||.||::.|||||||||:||..||:|||:.|....|  :..::..|..||
  Rat   438 VLCGVIAAFMAFLVELSDLVDLSSIGTLLAYSLVAFSVLVLRYQPDQNLSSCKKEKSDSMAVELE 502

  Fly   446 QDRPCALWRRIFNLNG------------QTVPTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDL 498
            .....:......:..|            .|.||.::.|||....:|.:|..:....||.::...|
  Rat   503 PGLELSSCMEPMSPEGTPGIARGLCMPMDTTPTLRSGRIVYGCASLLALLLVFLCLILVQWSTQL 567

  Fly   499 ANVTSFDGIKLVLGTIPLAVLLL------VISRQPTSGVKLSFKVPLVPWLPGISILINIYLMIK 557
                 |.| ..||..:.:::.||      ||.|||.|.:.|.||||.:|.||.:||.:|||||::
  Rat   568 -----FSG-NPVLIAVAVSLFLLTVGVVTVIWRQPQSTIPLHFKVPALPVLPVLSIFVNIYLMMQ 626

  Fly   558 LDILTWIRFSIWIAIGLAIFLAYGIRHSRLRQREQR 593
            :...|||||.||:.||.||:..|||:||...:.:|:
  Rat   627 MTTGTWIRFGIWMVIGFAIYFGYGIQHSLEEKNDQQ 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	256/603 (42%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	28/49 (57%)
LOC292543	XP_006228084.2	2A0303	53..656	CDD:273330	259/612 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351250
Domainoid	1	1.000	457	1.000	Domainoid score	I470
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1161
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm8968
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910