DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and Slc7a14

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_766449.1	Gene:	Slc7a14 / 241919	MGIID:	3040688	Length:	771	Species:	Mus musculus

Alignment Length:	692	Identity:	266/692 - (38%)
Similarity:	398/692 - (57%)	Gaps:	126/692 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AEYYGMPSWSVTNAFRVLTRKKPLEDSNE---------SKLAKVLSAFDLTALGIGSTLGVGVYV 60
            |.:|.|.|       |:| |.||:|...|         :|||:||:..||.:||:||.:|.|:||
Mouse    17 AAWYAMHS-------RIL-RTKPVESMLEGTGTTSAHGTKLAQVLTTVDLISLGVGSCVGTGMYV 73

  Fly    61 LAGEVSKQYAGPAVVVSFLIAAIASIFAGLCYAEFGARVPK-AGSAYIYSYVTIGEFIAFLIGWN 124
            ::|.|:|:.|||.|:|||:|||:|||.:|:||||||.|||| .||||.|||||:|||:||.||||
Mouse    74 VSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWN 138

  Fly   125 LILEYAIGSASVVKGLSTYLDQLCGNPMSSFL----GTHMPLNIEGMG--AYPDLFAFVVTILFS 183
            |||||.||:|:....||:..|.|..:.:|.::    ||   ||..|.|  :||||.|.|:.::.:
Mouse   139 LILEYLIGTAAGASALSSMFDSLANHSISRWMVDTVGT---LNGLGKGEESYPDLLALVIAVIVT 200

  Fly   184 LAIAVGAKESTRVNNVFTMLNLGVVLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMPYGVSGI 248
            :.:|:|.|.|...|||..:|||.|.:|::|||||.::...|:           :|.|:|:|.||:
Mouse   201 IIVALGVKNSVGFNNVLNVLNLAVWVFIMIAGLFFINGKYWA-----------EGQFLPHGWSGV 254

  Fly   249 IKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEK 313
            ::|||.|||.|||||.|||.|||||||..|||:|:..||.:...||..||.:||:|:||:..|.:
Mouse   255 LQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSMILTLMVPYYAIDTE 319

  Fly   314 APLPHVFRINGWHVAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTP 378
            :||..:|..:|::.|::||:||::.||..|::|::||:||:::||:.|||||:||..:|...:||
Mouse   320 SPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETP 384

  Fly   379 FKGTMITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYEVDD-------------- 429
            ....:::|.|..:|:.:.:|..|:.||||||||||::|:.|||:|||:.:.
Mouse   385 VVACIVSGFLAALLSLLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHT 449

  Fly   430 RRESRIVAN--------------------------------------GRA--------------- 441
            :::..|:|:                                      |::
Mouse   450 KKKEGILADCEKETCSPVSEGEEFSSPATNTCGAKNLPSLGDNEMLIGKSDKSAYNVNHPNYGTV 514

  Fly   442 ---TGLEQDR--------------PCALWRRI-FNLNGQ-TVPTKQTSRIVTYSVTLFSLWCMVF 487
               ||:|.|.              |.....|| ..|.|: ..||..|...||..|.|..:...:|
Mouse   515 DMTTGIEADESENIYLIKLKKLIGPRYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIF 579

  Fly   488 SQILTKFEEDLANVTSFDGIKLVLGTIPLAVLLLVISRQPTSGVKLSFKVPLVPWLPGISILINI 552
            ...:....|.::..:.:..:.:||..:.::||:.||.:||.:..||.:..|.:|::|..::|:||
Mouse   580 CSFIIFGSEYISGQSWWAILLVVLMMLLISVLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNI 644

  Fly   553 YLMIKLDILTWIRFSIWIAIGLAIFLAYGIRHSRLR--QREQ 592
            |||:||..:|||||::|..:|:.|:..|||.:|.|.  .|||
Mouse   645 YLMLKLSTITWIRFAVWCFVGMLIYFGYGIWNSTLEISAREQ 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	257/666 (39%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	22/49 (45%)
Slc7a14	NP_766449.1	2A0303	43..677	CDD:273330	250/647 (39%)
Slc7a14	NP_766449.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820