DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and SLC7A11

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_011530104.1	Gene:	SLC7A11 / 23657	HGNCID:	11059	Length:	506	Species:	Homo sapiens

Alignment Length:	502	Identity:	107/502 - (21%)
Similarity:	199/502 - (39%)	Gaps:	105/502 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IGSTLGVGVYVLAGEVSKQYAGPAVVVS-FLIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTI 113
            ||:.:|.|:::....|.:......:.:: :.:..:.|:|..|.|||.|..:.|:|..|.|.....
Human    54 IGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVF 118

  Fly   114 GEFIAFLIGW-NLILEYAIGSASVVKGLSTYLDQLCGNPMSSFLGTHMP-LNIEGMGAYPDLFAF 176
            |...||:..| .|::.....:|.:......|:.:    |.  |:...:| |.|:.:.|   :...
Human   119 GPLPAFVRVWVELLIIRPAATAVISLAFGRYILE----PF--FIQCEIPELAIKLITA---VGIT 174

  Fly   177 VVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLFVIIAG---LFKVSSSNW---------SIPKS 229
            ||.:|.|::::    .|.|:....|...|..:|.:|:.|   |.|..:.|:         ||.:.
Human   175 VVMVLNSMSVS----WSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRL 235

  Fly   230 QVPEGYGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAY 294
            .:...||                   .|.:.|:..:....||.:||:|:||.|:.:|:|::.:.|
Human   236 PLAFYYG-------------------MYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGY 281

  Fly   295 FGVSTVLTMMLPYFE--QDEKAPLPHVFRI-------NGWHVAEYVVSIGAMFGLCSSMMGAMFP 350
                 ||| .:.||.  ..|:..|.:...:       ..:.:|..:....:.||   ||.|.:|.
Human   282 -----VLT-NVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFG---SMNGGVFA 337

  Fly   351 LPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLVNMMSIGTLLAYSM 415
            :.|:.:..|.:|.|.:.|..|..:..||....::...||.|:....:|..|:|.:|....|...:
Human   338 VSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGL 402

  Fly   416 VASCVLMLRYEVDDRRESRIVANGRATGLEQDRPCALWRRIFNLNGQTVPTKQTSRIVTYSVTLF 480
            ..:.::.|||:..|                ..||                    .::..:...||
Human   403 AVAGLIYLRYKCPD----------------MHRP--------------------FKVPLFIPALF 431

  Fly   481 SLWCMVFSQILTKFEEDLANVTSFDGIKLVLGTIPLAVLLLVISRQP 527
            |..|: |...|:.:.:..:...   |..:.|..:|...|.::..::|
Human   432 SFTCL-FMVALSLYSDPFSTGI---GFVITLTGVPAYYLFIIWDKKP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	107/502 (21%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
SLC7A11	XP_011530104.1	2A0308	1..483	CDD:273332	107/502 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850