DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5535 and Slc7a5

DIOPT Version :9

Sequence 1:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_035534.2	Gene:	Slc7a5 / 20539	MGIID:	1298205	Length:	512	Species:	Mus musculus

Alignment Length:	436	Identity:	93/436 - (21%)
Similarity:	174/436 - (39%)	Gaps:	68/436 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RKKPLE---------DSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAV-VVSF 78
            |:|.||         :.....|.:.::..:..|:.:|:.:|.|::|....|.|:...|.: :|.:
Mouse    26 REKMLEARRGDGADPEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVW 90

  Fly    79 LIAAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTY 143
            .:..:.||...|||||.|..:.|:|..|.|.....|...|||..|..:|        :::..|.|
Mouse    91 AVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELL--------IIRPSSQY 147

  Fly   144 LDQLCGNPMSSFLGTHMPLNIEGMGAYPD----LFAFVVTILFSLAIAVGAKESTRVNNVFTMLN 204
            :       ::....|::...:......|:    |.|.:..:|.:.......|.:|||.:.|....
Mouse   148 I-------VALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAK 205

  Fly   205 LGVVLFVIIAGLFKVSSSNWSIPKSQVPEGYGDGGFMP---------YGVSGIIKGAAVCFYGFI 260
            |..:..:|:.|..::...          .|.||...:.         ..|..|:.......:.:.
Mouse   206 LLALALIILLGFIQMGKD----------MGQGDASNLQQKLSFEGTNLDVGNIVLALYSGLFAYG 260

  Fly   261 GFDCIATAGEEAKNPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFE--------QDEKAPLP 317
            |::.:....||..||.:::|.|:|:||.::.|.|     ||| .|.||.        ..|...:.
Mouse   261 GWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVY-----VLT-NLAYFTTLSTNQMLTSEAVAVD 319

  Fly   318 HVFRINGWH--VAEYVVSIGAMFGLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFK 380
                ...:|  |..:::.:........|:.|::|...|:.|..|.:|.|...|..|..:..||..
Mouse   320 ----FGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSVLSMIHPQLLTPVP 380

  Fly   381 GTMITGMLTGILAAVFNLSQLVNMMSIGTLLAYSMVASCVLMLRYE 426
            ..:.|.::|.:.|...::..::|..|....|..::....::.||::
Mouse   381 SLVFTCIMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFK 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	93/436 (21%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617
Slc7a5	NP_035534.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		4/16 (25%)
Slc7a5	NP_035534.2	2A0308	35..511	CDD:273332	89/427 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940